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To investigate the biological role of growth differentiation factor 8 (GDF8) in the regulation of steroidogenesis in human granulosa-lutein (hGL) cells.Experimental study.Academic medical center.In vitro fertilization patients who provided hGL cells.Cultured hGL cells treated with recombinant human GDF8 for 24 hours.Expression of steroidogenic enzymes and steroid production in primary cultures of...
Objective: Reactive oxygen species have been implicated widely in causing deficient sperm viability and function due to membrane lipid peroxidation. Low concentrations have a positive effect on both sperm motion and capacitation (de Lamirande E, et al. Int J Andrology 1993; 16:21-5 and Bize I, et al. Biol Reprod 1991;44:398-403). Lowering H 2 O 2 levels with catalase or protecting...
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