Search results for: Sebastian E. Winter

Items from 1 to 15 out of 15 results

article

Using Enteric Pathogens to Probe the Gut Microbiota

Luisella Spiga, Sebastian E. Winter

Trends in Microbiology > 2019 > 27 > 3 > 243-253

Enteric pathogens have evolved to manipulate the interface between the host and commensal microbial communities, making these pathogenic organisms superb research tools to interrogate the function of the gut microbiota during inflammatory flares. Here, we provide an overview of conceptual insights gained from experimental infection with enteric pathogens, such as Salmonella enterica serovar Typhimurium...

article

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

Naoteru Miyata, Lindsey L. Morris, Qing Chen, Curtis Thorne, more

Cell Reports > 2018 > 24 > 9 > 2342-2355

Physiologic microbe-host interactions in the intestine require the maintenance of the microbiota in a luminal compartment through a complex interplay between epithelial and immune cells. However, the roles of mucosal myeloid cells in this process remain incompletely understood. In this study, we identified that decreased myeloid cell phagocytic activity promotes colon tumorigenesis. We show that this...

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Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Caroline C. Gillis, Elizabeth R. Hughes, Luisella Spiga, Maria G. Winter, more

Cell Host & Microbe > 2018 > 23 > 4 > 570

article

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Caroline C. Gillis, Elizabeth R. Hughes, Luisella Spiga, Maria G. Winter, more

Cell Host & Microbe > 2018 > 23 > 1 > 54-64.e6

During Salmonella-induced gastroenteritis, mucosal inflammation creates a niche that favors the expansion of the pathogen population over the microbiota. Here, we show that Salmonella Typhimurium infection was accompanied by dysbiosis, decreased butyrate levels, and substantially elevated lactate levels in the gut lumen. Administration of a lactate dehydrogenase inhibitor blunted lactate production...

article

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

Andrea K. Erickson, Palmy R. Jesudhasan, Melinda J. Mayer, Arjan Narbad, more

Cell Host & Microbe > 2018 > 23 > 1 > 77-88.e5

RNA viruses exist in genetically diverse populations due to high levels of mutations, many of which reduce viral fitness. Interestingly, intestinal bacteria can promote infection of several mammalian enteric RNA viruses, but the mechanisms and consequences are unclear. We screened a panel of 41 bacterial strains as a platform to determine how different bacteria impact infection of poliovirus, a model...

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An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate

Luisella Spiga, Maria G. Winter, Tatiane Furtado de Carvalho, Wenhan Zhu, more

Cell Host & Microbe > 2017 > 22 > 3 > 291-301.e6

The mucosal inflammatory response induced by Salmonella serovar Typhimurium creates a favorable niche for this gut pathogen. Conventional wisdom holds that S. Typhimurium undergoes an incomplete tricarboxylic acid (TCA) cycle in the anaerobic mammalian gut. One change during S. Typhimurium-induced inflammation is the production of oxidized compounds by infiltrating neutrophils. We show that inflammation-derived...

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Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis

Elizabeth R. Hughes, Maria G. Winter, Breck A. Duerkop, Luisella Spiga, more

Cell Host & Microbe > 2017 > 21 > 2 > 208-219

Intestinal inflammation is frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is characterized by a reduced abundance of obligate anaerobic bacteria and an expansion of facultative Proteobacteria such as commensal E. coli. The mechanisms enabling the outgrowth of Proteobacteria during inflammation are incompletely understood. Metagenomic sequencing revealed bacterial...

article

Enterococcus faecalis: E. coli’s Siderophore-Inducing Sidekick

Elizabeth R. Hughes, Sebastian E. Winter

Cell Host & Microbe > 2016 > 20 > 4 > 411-412

Many infectious diseases involve polymicrobial infections, which are characterized by synergistic interactions between different microorganisms colonizing a host. In this issue of Cell Host & Microbe, Keogh et al. (2016) show that Enterococcus faecalis promotes Escherichia coli biofilm formation in low-iron conditions, thus facilitating polymicrobial growth.

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Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

Fabian Rivera-Chávez, Lillian F. Zhang, Franziska Faber, Christopher A. Lopez, more

Cell Host & Microbe > 2016 > 19 > 4 > 443-454

The mammalian intestine is host to a microbial community that prevents pathogen expansion through unknown mechanisms, while antibiotic treatment can increase susceptibility to enteric pathogens. Here we show that streptomycin treatment depleted commensal, butyrate-producing Clostridia from the mouse intestinal lumen, leading to decreased butyrate levels, increased epithelial oxygenation, and aerobic...

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Why related bacterial species bloom simultaneously in the gut: principles underlying the ‘Like will to like’ concept

Sebastian E. Winter, Andreas J. Bäumler

Cellular Microbiology > 16 > 2 > 179 - 184

The large intestine is host to a complex ecological community composed predominantly of obligate anaerobic bacteria belonging to the classes Bacteroidia and Clostridia. This community confers benefits through its metabolic activities and host interactions. However, a microbial imbalance (dysbiosis) characterized by a decreased abundance of Clostridia and a bloom of facultative anaerobic Proteobacteria...

article

Salmonella, the host and its microbiota

Parameth Thiennimitr, Sebastian E Winter, Andreas J Bäumler

Current Opinion in Microbiology > 2012 > 15 > 1 > 108-114

The intestine is host to a diverse bacterial community whose structure, at the phylum level, is maintained through unknown mechanisms. Acute inflammation triggered by enteric pathogens, such as Salmonella enterica serotype Typhimurium (S. Typhimurium), is accompanied by changes in the bacterial community structure marked by an outgrowth of the pathogen. Recent studies show that S. Typhimurium can...

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Intestinal and chronic infections: Salmonella lifestyles in hostile environments

Andreas J. Bäumler, Sebastian E. Winter, Parameth Thiennimitr, Josep Casadesús

Environmental Microbiology Reports > 3 > 5 > 508 - 517

The main disease syndromes caused by Salmonella serovars in immunocompetent individuals are gastroenteritis and typhoid fever. These syndromes differ with regard to the host niches in which Salmonella serovars grow and survive to ensure their transmission. During gastroenteritis, non‐typhoidal Salmonella serovars such as Salmonella enterica serovar Typhimurium (S. Typhimurium) use their virulence...

article

The Blessings and Curses of Intestinal Inflammation

Sebastian E. Winter, A. Marijke Keestra, Renée M. Tsolis, Andreas J. Bäumler

Cell Host & Microbe > 2010 > 8 > 1 > 36-43

The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the lumenal secretion of antimicrobial peptides, as well as the release of cytokines in tissue that recruit and activate...

article

Heterologous prime–boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction

Victòria E. Sevil Domènech, Klaus Panthel, Sebastian E. Winter, Holger Rüssmann

Vaccine > 2008 > 26 > 15 > 1879-1886

Pre-existing anti-vector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. In the present study, we demonstrate that heterologous prime–boost immunizations using attenuated serovar Typhimurium and serovar...

article

Pre-existing anti-Salmonella vector immunity prevents the development of protective antigen-specific CD8 T-cell frequencies against murine listeriosis

Victòria E. Sevil Domènech, Klaus Panthel, Katrin M. Meinel, Sebastian E. Winter, more

Microbes and Infection > 2007 > 9 > 12-13 > 1447-1453

Our laboratory has focused its research on the use of the type III secretion system of Salmonella enterica serovar Typhimurium to translocate heterologous antigens directly into the cytosol of antigen-presenting cells. We have previously reported that the single oral immunization of mice with a recombinant Salmonella aroA/sptP mutant strain expressing the translocated Yersinia outer protein E fused...

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Keywords

GUT MICROBIOTA (4)
ANTI-VECTOR IMMUNITY (2)
CD8 T CELL (2)
MICROBIAL METABOLISM (2)
SALMONELLA (2)
TYPE III SECRETION SYSTEM (2)
BACTERIA (1)
BACTERIAL METABOLISM (1)
BACTERIAL RESPIRATION (1)
CCC COMPLEX (1)
CO-INFECTION (1)
COLON CANCER (1)
COMMD1 (1)
COX-2 (1)
DYSBIOSIS (1)
ENTERIC PATHOGENS (1)
ENTERIC VIRUS (1)
EVOLUTION (1)
FITNESS (1)
FORMATE METABOLISM (1)
GOBLET CELLS (1)
HETEROLOGOUS PRIME–BOOST IMMUNIZATIONS (1)
HOST METABOLISM DURING INFECTION (1)
HOST-MICROBE INTERACTION (1)
INTESTINAL INFLAMMATION (1)
INTESTINAL MICROBIOTA (1)
LISTERIOSIS (1)
METAGENOMICS (1)
MICROBIOTA (1)
MYELOID CELLS (1)
PGE-2 (1)
POLIOVIRUS (1)
PROTECTIVE IMMUNITY (1)
RECOMBINATION (1)
SALMONELLA ENTERICA SEROVAR TYPHIMURIUM (1)
SALMONELLA ENTERICA SEROVAR TYPHIMURIUM AND SEROVAR DUBLIN (1)
TUFT CELLS (1)
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Elsevier (13)
Wiley (2)

INFONA - science communication portal

Search results for: Sebastian E. Winter

Using Enteric Pathogens to Probe the Gut Microbiota

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis

Enterococcus faecalis: E. coli’s Siderophore-Inducing Sidekick

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

Why related bacterial species bloom simultaneously in the gut: principles underlying the ‘Like will to like’ concept

Salmonella, the host and its microbiota

Intestinal and chronic infections: Salmonella lifestyles in hostile environments

The Blessings and Curses of Intestinal Inflammation

Heterologous prime–boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction

Pre-existing anti-Salmonella vector immunity prevents the development of protective antigen-specific CD8 T-cell frequencies against murine listeriosis

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