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Background: TWA (T wave alternans) represents a risk for development of ventricular tachycardia (VT). In CAD (coronary artery disease) patients there is a strong correlation between occurrence of VT and electrical instability measured by TWA analyses. For idiopathic VT patients are only few data available.Methods: To determine the incidence of TWA, we studied 10 patients with idiopathic VT, and...
Background: Children born with transposition of the great vessels currently undergo an arterial switch procedure in the neonatal period, and are subsequently largely asymptomatic. There is a low incidence of perfusion defects in this population.Methods: We assessed myocardial blood flow (MBF) and myocardial vascular resistance (MVR) at rest and during maximal hyperemia using N-13 ammonia PET before...
We conducted an initial clinical trial of our newly developed cardiac magnetic resonance imaging (CMRI) system. Our CMRI system allows continuous dynamic acquisition and display of any scan plane at 16 images/second without the need for cardiac gating or breath-holding. We evaluated LV function in 74 patients to compare the clinical utility of CMRI to echocardiography (ECHO), the current gold standard...
Background: Lipid lowering therapy may improve coronary vascular function by a direct vascular effect of lipid concentration.Methods: We investigated the acute effect of a single LDL-apheresis (LDL-A) on myocardial perfusion by measuring myocardial blood flow (MBF in ml/min/g) with N-13 ammonia/PET at rest and vasodilatory capacity during adenosine hyperemia (140 mg/kg/min for 5 min,) in 10 patients...
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