Search results for: Joanna Mika

Items from 1 to 20 out of 46 results

article

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

Gabriela Mazur, Katarzyna Pańczyk‐Straszak, Anna Rapacz, Jan Kiszela, more

Chemical Biology & Drug Design > 101 > 2 > 278 - 325

A series of 10 aminoalkanol derivatives of 5‐chloro‐2‐ or 5‐chloro‐4‐methylxanthone was synthetized and evaluated for anticonvulsant properties (MES test, mice, intraperitoneal) and compared with neurotoxicity rotarod test (NT, mice, i.p.). The best results both in terms of anticonvulsant activity and protective index value were obtained for 3: 5‐chloro‐2‐([4‐hydroxypiperidin‐1‐yl]methyl)‐9H‐xanthen‐9‐one...

article

The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain

Katarzyna Pawlik, Anna Piotrowska, Klaudia Kwiatkowski, Katarzyna Ciapała, more

Immunology > 159 > 4 > 413 - 428

A growing body of evidence has indicated that the release of nociceptive factors, such as interleukins and chemokines, by activated immune and glial cells has crucial significance for neuropathic pain generation and maintenance. Moreover, changes in the production of nociceptive immune factors are associated with low opioid efficacy in the treatment of neuropathy. Recently, it has been suggested that...

article

Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies

Anna Piotrowska, Ewelina Rojewska, Katarzyna Pawlik, Grzegorz Kreiner, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2018 > 1864 > 10 > 3418-3437

It has been suggested that CXCR3 is important for nociception. Our experiments were conducted to evaluate involvement of CXCR3 and its ligands (CXCL4, CXCL9, CXCL10, CXCL11/CCL21) in neuropathic pain. Our studies give new evidence that intrathecal administration of each CXCR3 ligand induces pain-like behaviour in naive mice that occurs shortly after injection due to its location of neurons, which...

article

Antinociceptive effects of novel histamine H₃ and H₄ receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse

Katarzyna Popiolek‐Barczyk, Dorota Łażewska, Gniewomir Latacz, Agnieszka Olejarz, more

British Journal of Pharmacology > 175 > 14 > 2897 - 2910

Background and Purpose The histaminergic system is a promising target for the development of new analgesics, as histamine H₃ and H₄ receptors are expressed in regions concerned with nociceptive transmission. Here we have determined the analgesic effects of new H₃ and H₄ receptor antagonists in naive and neuropathic mice. Experimental Approach We used chronic constriction injury (CCI) to the sciatic...

article

Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target – Evidence from a mouse diabetic neuropathy model

Magdalena Zychowska, Ewelina Rojewska, Anna Piotrowska, Grzegorz Kreiner, more

International Immunopharmacology > 2017 > 52 > C > 261-271

Chemokine signaling has been implicated in the pathogenesis of diabetic neuropathy; however, the involvement of the chemokine CC motif ligand 1 (CCL1)-chemokine CC motif receptor 8 (CCR8) interaction remains unknown. The goal of this study was to examine the role of CCL1-CCR8 signaling interplay in the development of hypersensitivity and in opioid effectiveness in diabetic neuropathy.Primary glial...

article

Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy

Joanna Starnowska, Karel Guillemyn, Wioletta Makuch, Joanna Mika, more

European Journal of Pharmaceutical Sciences > 2017 > 104 > C > 221-229

A bifunctional peptide containing an opioid and nociceptin receptor-binding pharmacophore, H-Dmt-D-Arg-Aba-β-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2 (KGNOP1), was tested for its analgesic properties when administered intrathecally in naïve and chronic constriction injury (CCI)-exposed rats with neuropathy-like symptoms. KGNOP1 significantly increased the acute pain threshold, as measured by the tail-flick...

article

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats

Klaudia Kwiatkowski, Anna Piotrowska, Ewelina Rojewska, Wioletta Makuch, more

Journal of Neuroimmune Pharmacology > 2017 > 12 > 3 > 402-419

Increasing evidence has indicated that activated glial cells releasing nociceptive factors, such as interleukins and chemokines, are of key importance for neuropathic pain. Significant changes in the production of nociceptive factors are associated with the low effectiveness of opioids in neuropathic pain. Recently, it has been suggested that CCL2/CCR2 signaling is important for nociception. Here,...

article

Dataset of botulinum toxin A influence on interleukins under neuropathy

Magdalena Zychowska, Ewelina Rojewska, Wioletta Makuch, Siro Luvisetto, more

Data in Brief > 2016 > 9 > C > 1020-1023

Our data show that botulinum toxin A (BoNT/A) didn’t influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta and...

article

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain

Magdalena Zychowska, Ewelina Rojewska, Wioletta Makuch, Siro Luvisetto, more

European Journal of Pharmacology > 2016 > 791 > C > 377-388

Botulinum neurotoxin serotype A (BoNT/A) shows antinociceptive properties, and its clinical applications in pain therapy are continuously increasing. BoNT/A specifically cleaves SNAP-25, which results in the formation of a non-functional SNARE complex, thereby potently inhibiting the release of neurotransmitters and neuropeptides, including those involved in nociception. The aim of the present study...

article

Maraviroc reduces neuropathic pain through polarization of microglia and astroglia – Evidence from in vivo and in vitro studies

Anna Piotrowska, Klaudia Kwiatkowski, Ewelina Rojewska, Wioletta Makuch, more

Neuropharmacology > 2016 > 108 > C > 207-219

Recent studies suggest that CCR5 and its ligands are important regulators for the development of neuropathic pain and that their modulation can have some beneficial properties. Therefore, the aim of our study was to investigate the influence of maraviroc (MVC, a CCR5 antagonist) on glial polarization markers and intracellular signaling pathways in the spinal cord 7 days after chronic constriction...

article

Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain — In vivo and in vitro evidence

Anna Piotrowska, Klaudia Kwiatkowski, Ewelina Rojewska, Joanna Slusarczyk, more

Journal of Neuroimmunology > 2016 > 297 > C > 9-19

The repeated administration of microglial inhibitor (minocycline) and CCR2 antagonist (RS504393) attenuated the neuropathic pain symptoms in rats following chronic constriction injury of the sciatic nerve, which was associated with decreased spinal microglia activation and the protein level of CCL2 and CCR2. Furthermore, in microglia primary cell cultures minocycline downregulated both CCL2 and CCR2...

article

Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine

Dominika Pilat, Anna Piotrowska, Ewelina Rojewska, Agnieszka Jurga, more

Molecular and Cellular Neuroscience > 2016 > 71 > C > 114-124

Currently, the low efficacy of antinociceptive drugs for the treatment of neuropathic pain is a major therapeutic problem. Here, we show the potential role of interleukin (IL)-18 signaling in this phenomenon. IL-18 is an important molecule that performs various crucial functions, including the alteration of nociceptive transmission in response to neuropathic pain. We have studied the changes in the...

article

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model

Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch, Barbara Przewlocka, more

Neuropharmacology > 2016 > 102 > C > 80-91

Recent studies have highlighted the involvement of the kynurenine pathway in the pathology of neurodegenerative diseases, but the role of this system in neuropathic pain requires further extensive research. Therefore, the aim of our study was to examine the role of kynurenine 3-monooxygenase (Kmo), an enzyme that is important in this pathway, in a rat model of neuropathy after chronic constriction...

article

Retracted: Anti‐inflammatory properties of tianeptine on lipopolysaccharide‐induced changes in microglial cells involve toll‐like receptor‐related pathways

Joanna Slusarczyk, Ewa Trojan, Katarzyna Glombik, Anna Piotrowska, more

Journal of Neurochemistry > 136 > 5 > 958 - 970

Accumulating evidence suggests that activation of microglia plays a key role in the pathogenesis of depression. Activated microglia produce a wide range of factors whose prolonged or excessive release may lead to brain disorders. Thus, the inhibition of microglial cells may be beneficial in the treatment of depressive diseases. Tianeptine is an atypical antidepressant drug with proven clinical efficacy,...

article

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

Klaudia Kwiatkowski, Anna Piotrowska, Ewelina Rojewska, Wioletta Makuch, more

Progress in Neuro-Psychopharmacology and Biological Psychiatry > 2016 > 64 > C > 68-78

Targeting chemokine signaling pathways is crucial in neuropathy development. In this study, we investigated the influence of chronic administration of maraviroc (CCR5 antagonist) on nociception and opioid effectiveness during neuropathy, which develops as a result of chronic constriction injury (CCI) of the sciatic nerve. To investigate the mechanism of action of maraviroc, we measured the expression...

article

IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model

Dominika Pilat, Ewelina Rojewska, Agnieszka M. Jurga, Anna Piotrowska, more

European Journal of Pharmacology > 2015 > 764 > Complete > 240-248

An interesting research and therapeutic problem is the reduced beneficial efficacy of opioids in the treatment of neuropathic pain. The present study sought to investigate the potential role of IL-1 family members in this phenomenon. We studied the time course of changes in IL-1alpha, IL-1beta, IL-1 receptor type I and IL-1 receptor antagonist mRNA and protein levels experienced by rats after chronic...

article

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics

Karel Guillemyn, Patrycia Kleczkowska, Anna Lesniak, Jolanta Dyniewicz, more

European Journal of Medicinal Chemistry > 2015 > 92 > C > 64-77

A reported mixed opioid agonist – neurokinin 1 receptor (NK1R) antagonist 4 (Dmt-D-Arg-Aba-Gly-(3′,5′-(CF₃)₂)NMe-benzyl) was modified to identify important features in both pharmacophores. The new dual ligands were tested in vitro and subsequently two compounds (lead structure 4 and one of the new analogues 22, Dmt-D-Arg-Aba-β-Ala-NMe-Bn) were selected for in vivo behavioural assays, which were conducted...

article

The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain

Magdalena Zychowska, Ewelina Rojewska, Wioletta Makuch, Barbara Przewlocka, more

European Journal of Pharmacology > 2015 > 749 > Complete > 115-123

The analgesic properties of antidepressants are often used in the treatment of neuropathy; however their influence on glial cells in maintaining neuropathic pain is unknown. Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence...

article

A new potential mechanism of action of tianeptine – the effect on microglial cell activation

Joanna Slusarczyk, Ewa Trojan, Anna Piotrowska, Katarzyna Glombik, more

SpringerPlus > 2015 > 4 > 1 > 1-32

article

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

Ewelina Rojewska, Katarzyna Popiolek-Barczyk, Agnieszka M. Jurga, Wioletta Makuch, more

Journal of Neuroimmunology > 2014 > 277 > 1-2 > 57-66

In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline diminished the pronociceptive (IL-6, IL-18), but not antinociceptive (IL-1alpha, IL-4, IL-10) cytokines at the spinal cord level. In vitro primary cell culture studies have shown that MMP-9, TIMP-1, IL-1beta, IL-1alpha, IL-6, IL-10,...

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Search results for: Joanna Mika

Promising anticonvulsant and/or analgesic compounds among 5‐chloro‐2‐ or 5‐chloro‐4‐methyl derivatives of xanthone coupled to aminoalkanol moieties—Design, synthesis and pharmacological evaluation

The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain

Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies

Antinociceptive effects of novel histamine H₃ and H₄ receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse

Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target – Evidence from a mouse diabetic neuropathy model

Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats

Dataset of botulinum toxin A influence on interleukins under neuropathy

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain

Maraviroc reduces neuropathic pain through polarization of microglia and astroglia – Evidence from in vivo and in vitro studies

Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain — In vivo and in vitro evidence

Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model

Retracted: Anti‐inflammatory properties of tianeptine on lipopolysaccharide‐induced changes in microglial cells involve toll‐like receptor‐related pathways

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – Neurokinin-1 antagonist peptidomimetics

The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain

A new potential mechanism of action of tianeptine – the effect on microglial cell activation

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

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