Maureen E. Hoatlin

article

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

Zhijiang Yan, Rong Guo, Manikandan Paramasivam, Weiping Shen, more

Molecular Cell > 2012 > 47 > 1 > 61-75

The Fanconi anemia (FA) protein network is necessary for repair of DNA interstrand crosslinks (ICLs), but its control mechanism remains unclear. Here we show that the network is regulated by a ubiquitin signaling cascade initiated by RNF8 and its partner, UBC13, and mediated by FAAP20, a component of the FA core complex. FAAP20 preferentially binds the ubiquitin product of RNF8-UBC13, and this ubiquitin-binding...

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Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg

Henri J. van de Vrugt, Mireille Koomen, Sietske Bakker, Mariska A.D. Berns, more

DNA Repair > 2011 > 10 > 12 > 1252-1261

Fanconi anemia (FA) is a heritable disease characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. The 15 identified FA genes operate in a molecular pathway to preserve genomic integrity. Within this pathway the FA core complex operates as an ubiquitin ligase that activates the complex of FANCD2 and FANCI to coordinate DNA repair. The FA core complex is formed by...

article

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Zhijiang Yan, Mathieu Delannoy, Chen Ling, Danielle Daee, more

Molecular Cell > 2010 > 37 > 6 > 865-878

FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks,...

article

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

Igor Landais, Sanne Hiddingh, Matthew McCarroll, Chao Yang, more

Molecular Cancer > 2009 > 8 > 1 > 1-13

Background The Fanconi anemia (FA) pathway is a multigene DNA damage response network implicated in the repair of DNA lesions that arise during replication or after exogenous DNA damage. The FA pathway displays synthetic lethal relationship with certain DNA repair genes such as ATM (Ataxia Telangectasia Mutated) that are frequently mutated in tumors. Thus, inhibition of FANCD2 monoubiquitylation (FANCD2-Ub),...

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The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC

France Léveillé, Miriam Ferrer, Annette L. Medhurst, El Houari Laghmani, more

DNA Repair > 2006 > 5 > 5 > 556-565

The Fanconi anemia (FA) protein FANCE is an essential component of the nuclear FA core complex, which is required for monoubiquitination of the downstream target FANCD2, an important step in the FA pathway of DNA cross-link repair. FANCE is predominantly localized in the nucleus and acts as a molecular bridge between the FA core complex and FANCD2, through direct binding of both FANCC and FANCD2....

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Yeast two-hybrid screens imply involvement of fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport

Tanja Y. Reuter, Annette L. Medhurst, Quinten Waisfisz, Yu Zhi, more

Experimental Cell Research > 2003 > 289 > 2 > 211-221

Mutations in one of at least eight different genes cause bone marrow failure, chromosome instability, and predisposition to cancer associated with the rare genetic syndrome Fanconi anemia (FA). The cloning of seven genes has provided the tools to study the molecular pathway disrupted in Fanconi anemia patients. The structure of the genes and their gene products provided few clues to their functional...

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Cloning and characterization of murine Fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary

Henri J. van de Vrugt, Ngan Ching Cheng, Yne de Vries, Martin A. Rooimans, more

Mammalian Genome > 2000 > 11 > 4 > 326-331

Abstract. Fanconi anemia (FA) is an autosomal recessive disorder in humans characterized by bone marrow failure, cancer predisposition, and cellular hypersensitivity to cross-linking agents such as mitomycin C and diepoxybutane. FA genes display a caretaker function essential for maintenance of genomic integrity. We have cloned the murine homolog of FANCA, the gene mutated in the major FA complementation...

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Search results for: Maureen E. Hoatlin

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC

Yeast two-hybrid screens imply involvement of fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport

Cloning and characterization of murine Fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary

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INFONA - science communication portal

Search results for: Maureen E. Hoatlin

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors

The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC

Yeast two-hybrid screens imply involvement of fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport

Cloning and characterization of murine Fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary

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