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BackgroundGenomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated with total serum IgE levels and asthma. In mice, this region harbors a locus control region for nearby TH2 cytokines, which is characterized by four Rad50 DNase I hypersensitive sites (RHS4–7). Among these, RHS7 seems to have the strongest impact on TH2 differentiation....
BackgroundGenome‐wide association studies (GWAS) repeatedly identified 1q23 (FCER1A), 5q31 (RAD50‐IL13 and IL4), and 12q13 (STAT6) as major susceptibility loci influencing the regulation of total serum IgE levels. As GWAS may be insufficient to capture causal variants, we performed fine‐mapping and re‐genotyping of the three loci using 1000 Genomes Project datasets.
MethodsLinkage disequilibrium...
BackgroundBoth FCER2 and FCER1A encode subunits of IgE receptors. Variants in FCER1A were previously identified as major determinants of IgE levels in genome‐wide association studies.
MethodsHere we investigated in detail whether FCER2 polymorphisms affect IgE levels alone and/or by interaction with FCER1A polymorphisms. To cover the genetic information of FCER2, 21 single‐nucleotide polymorphisms...
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