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The aim of the present study was to develop a simple method to measure plasma levels of propafenone by liquid chromatography with a C18 reverse-phase column and fluorescence detection, without previous derivatization of the sample. Linearity was assessed in the range from 50 to 1000 ng mL−1 and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were below 5%...
The aim of the present study was to develop a sensitive method to measure dextromethorphan and dextrorphan in urine by HPLC to support pharmacogenetic studies in ethnic groups. Linearity was assessed in the range: 0.01510 g mL1 for dextromethorphan and 1-10 g mL1 for dextrorphan. Inter and intra-day coefficients of variation were 10%. Limits of detection and quantitation were 0.003 g mL1 and 0.015...
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