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Abstract. Rationale: Most smokers report smoking has an anxiolytic effect, which may contribute to nicotine dependence. Objective: To examine effects in the social interaction test (SI) of anxiety after 4 weeks' self-administered nicotine (15 infusions of 0.03mg/kg, totalling 0.45mg/kg per day), and after 24 and 72h of withdrawal. The effect of exposure to the operant chamber on withdrawal responses...
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