Analyses of inactivation experiments performed on unperfused axons of the squid have been compared with the predictions of the Hodgkin-Huxley and the Hoyt mathematical models for the early (sodium) conductance. The results are in good agreement with the latter and in disagreement with the former.
It was observed that a reduction of the sodium chloride concentration in the external solution bathing a squid giant axon by replacement with sucrose resulted in marked decreases in the peak inward and steady-state outward currents through the axon membrane following a step decrease in membrane potential. These effects are quantitatively acounted for by the increase in series resistance resulting...
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