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In the present study, we systematically examined telmisartan, an angiotensin AT 1 receptor antagonist, on rosiglitazone-induced bone loss in ovariectomized spontaneously hypertensive rats. Telmisartan (5mg/kg/d, 90days) was found to be able to significantly alleviate rosiglitazone (10mg/kg/d, 90days)-induced decrease in BMD of femur and lumbar vertebrae. The BMD changes were associated with...
Prostaglandin E (PGE)-induced morphological changes of osteoblasts and its possible mechanisms were investigated in cultured calvaria and isolated osteoblasts from long bone fragments of neonatal rats. The control osteoblasts, either on the calvaria or isolated from the long bone fragments, were flat, polygonal in shape, and arranged in a monolayer under scanning electron microscopy (SEM) or phase...
Decreased bone mineral density (BMD) in the elderly increases the risk of hip fracture. Measurement of proximal femoral BMD can help us predict the risk of hip fracture, especially in the elderly. Since the BMD of proximal femur is usually measured on the unilateral side, we studied the risk of underestimation with measurement of unilateral proximal femur BMD in 266 normal Chinese women. In order...
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