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Background
Venlafaxine (selective serotonin and norepinephrine reuptake inhibitor) use has increased worldwide. However, the impact of venlafaxine on testes and sperm parameters has not been investigated.
Objectives
We evaluated venlafaxine impact on testicular and sperm parameters and verified whether the changes are reversible.
Methods
Animals from venlafaxine‐35 days and venlafaxine‐65 days...
Spermatozoa undergo sequential maturation changes during their transit along the epididymis. These changes are modulated by the epididymal epithelium and require a finely tuned gene expression. The Notch cell signaling pathway is a major regulator of cell fate decisions in several tissues, including the testis. Here, we evaluated the transcription and expression patterns of Notch components (Notch1‐3...
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