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The precise mechanism by which PPARγ activation by thiazolidinediones (TZDs) improves insulin sensitivity is still unclear. Recent studies have focused on the role of adipocytokines in metabolic control and their regulation by TZDs. In this study, we compared the chronic effects of antihyperglycemic doses of the TZD rosiglitazone, the β3-adrenoceptor agonist BRL-35135, and the PPARα agonist Wy-14,643...
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