Search results for: Alasdair J Gray

Items from 1 to 7 out of 7 results

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The RAPID-CTCA trial (Rapid Assessment of Potential Ischaemic Heart Disease with CTCA) — a multicentre parallel-group randomised trial to compare early computerised tomography coronary angiography versus standard care in patients presenting with suspected or confirmed acute coronary syndrome: study protocol for a randomised controlled trial

Alasdair J. Gray, Carl Roobottom, Jason E. Smith, Steve Goodacre, more

Trials > 2016 > 17 > 1 > 1-13

Background Emergency department attendances with chest pain requiring assessment for acute coronary syndrome (ACS) are a major global health issue. Standard assessment includes history, examination, electrocardiogram (ECG) and serial troponin testing. Computerised tomography coronary angiography (CTCA) enables additional anatomical assessment of patients for coronary artery disease (CAD) but has only...

article

High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study

Anoop S V Shah, Atul Anand, Yader Sandoval, Kuan Ken Lee, more

The Lancet > 2015 > 386 > 10012 > 2481-2488

Suspected acute coronary syndrome is the commonest reason for emergency admission to hospital and is a large burden on health-care resources. Strategies to identify low-risk patients suitable for immediate discharge would have major benefits. We did a prospective cohort study of 6304 consecutively enrolled patients with suspected acute coronary syndrome presenting to four secondary and tertiary...

article

CATCH a Glimpse of the Future∗

David E. Newby, Alasdair J. Gray

JACC: Cardiovascular Imaging > 2015 > 8 > 12 > 1414-1416

article

Early lactate clearance in septic patients with elevated lactate levels admitted from the emergency department to intensive care: Time to aim higher?

Craig A. Walker, David M. Griffith, Alasdair J. Gray, Deepankar Datta, more

Journal of Critical Care > 2013 > 28 > 5 > 832-837

Septic patients with hyperlactatemia have increased mortality rates, irrespective of hemodynamic and oxygen-derived variables. The aims of the study are the following: (1) to ascertain whether lactate clearance (LC) (percentage change in lactate over unit time) predicts mortality in septic patients admitted to intensive care directly from the emergency department and (2) to calculate the optimal “cut-off”...

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Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital

Daniel J. Antoine, James W. Dear, Philip Starkey Lewis, Vivien Platt, more

Hepatology > 58 > 2 > 777 - 787

Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would facilitate patient‐individualized treatment strategies. We investigated the potential of a panel of novel biomarkers (with enhanced liver expression or linked to the mechanisms of toxicity) to identify patients with acetaminophen‐induced acute...

article

Editor's Capsule Summary

Matthew J. Reed, Sarah S. Henderson, David E. Newby, Alasdair J. Gray

Annals of Emergency Medicine > 2011 > 58 > 3 > 250-256

We investigate the incidence of adverse events at 1 year in the cohort of emergency department (ED) syncope patients enrolled in the original Risk Stratification of Syncope in the Emergency Department (ROSE) study, the time to adverse event, and the test performance of the ROSE decision instrument to detect events at 1 year.This report details the 1-year follow-up of adult syncope patients presenting...

article

The ROSE (Risk Stratification of Syncope in the Emergency Department) Study

Matthew J. Reed, David E. Newby, Andrew J. Coull, Robin J. Prescott, more

Journal of the American College of Cardiology > 2010 > 55 > 8 > 713-721

The aim of this study was to develop and validate a clinical decision rule (CDR) to predict 1-month serious outcome and all-cause death in patients presenting with syncope to the emergency department.Syncope is a common, potentially serious condition accounting for many hospital admissions.This was a single center, prospective, observational study of adults presenting to the emergency department with...

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Search results for: Alasdair J Gray

High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study

CATCH a Glimpse of the Future∗

Early lactate clearance in septic patients with elevated lactate levels admitted from the emergency department to intensive care: Time to aim higher?

Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital

Editor's Capsule Summary

The ROSE (Risk Stratification of Syncope in the Emergency Department) Study

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