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In this study the modulatory effect of the proteinase kinase C β (PKC β) selective inhibitor enzastaurin on CA125 expression and shedding in ovarian cancer cells (OVCAR-3 cells) was investigated.OVCAR-3 cells were cultured in vitro and treated with increasing concentrations of carboplatin (2–1.000µM), paclitaxel (0.2–100nM) or enzastaurin (1–100µM) single agent. Growth inhibitory effects were evaluated...
Background. Uterine leiomyomas rarely cause pseudo-Meigs' syndrome with elevated serum CA 125 levels.Case. A 39-year-old patient with a large uterine leiomyoma is described. The associated massive ascites, pleural fluid, and increased CA 125 level all seemed to be related to the uterine tumor. Hydropic degenerating leiomyomas are characterized by focal accumulation of edema and collagen deposition...
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