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Purpose The pharmacokinetics of eltrombopag and its stimulation of platelet production were characterized in patients with chronic hepatitis C virus (HCV) infection to optimize an eltrombopag dosing regimen for treatment of HCV-related thrombocytopenia before and throughout peginterferon (pegIFN)-based antiviral therapy. Methods Population pharmacokinetic analysis for eltrombopag included 663 individuals...
Background: Eltrombopag is the first orally self-administered, small-molecule, nonpeptide thrombopoietin receptor agonist for the treatment of chronic idiopathic thrombocytopenic purpura.Objective: The aim of these studies was to assess the effect of food and antacids on the pharmacoki-netic and safety profiles of eltrombopag.Methods: Two independent, single-dose, open-label, randomized-sequence,...
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