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Optimization of regenerative medicine strategies includes the design of biomaterials, development of cell-seeding methods, and control of cell-biomaterial interactions within the engineered tissues. Among these steps, one paramount challenge is to non-destructively image the engineered tissues in their entirety to assess structure, function, and molecular expression. It is especially important to...
Current Laminar Optical Tomography (LOT) systems differ in their optical design, mainly in scanning mode strategies and detector selection. Herein, we investigate the design for an LOT system with an Electron Multiplying CCD camera in de-scanning mode. In de-scanning mode, the image of the detectors is scanned on the surface of the sample in conjunction with the raster scanned illumination spot. De-scanning...
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