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Background CDK5RAP3 was initially isolated as a binding protein of the CDK5 activator p35. Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3β phosphorylation, its in-depth mechanism has not been determined. Methods Following CDK5RAP3 overexpression or knock down, CDK5RAP3 signaling pathways were investigated in gastric...
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