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That evolution of longevity may depend on alterations in the expression of relatively few regulatory genes has been inferred from the rapid increase in lifespan during evolution of the hominid species (Cutler RG (1979) Mech Ageing Dev 9: 337–354). Also the inherent immortality of the embryonic stem cells implies that replicative senescence (Hayflick L (1997) Biochem Mosc 62: 1180–1190) as possibly...
It is suggested that the chaperone-activity of the SV40 T protein is responsible for the first step in the process of cellular immortalization in vitro: the extension of life span of most transfected cells. Further that an additional up-regulation of selected molecular chaperones is causal in the second step of the process: the rare acquisition of an unlimited cell division potential. Possibly the...
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