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To examine the risk factors associated with the odds of extreme Gleason upgrading at radical prostatectomy (RP) (defined as a Gleason prognostic group score increase of ≥2), we utilized a large, population-based cancer registry.The Surveillance, Epidemiologic, and End Results database was queried (2010-2011) for all patients diagnosed with Gleason 3 + 3 or 3 + 4 on prostate needle biopsy. Available...
To examine the risk factors associated with upstaging at inguinal lymph node dissection (ILND) in men with penile cancer and clinically negative lymph nodes (cN0) using a large US cancer database.The National Cancer Data Base was queried from 1998 to 2012 to identify men with penile cancer who underwent ILND and had complete clinical or pathologic node status available. Lymphovascular invasion (LVI)...
To characterize morbidity of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for testis cancer, we analyze a contemporary national database. PC-RPLND is the standard for residual radiographic masses ≥1 cm (nonseminoma) and positron emission tomography-avid masses ≥3 cm (seminoma). Morbidity for PC-RPLND is greater than primary RPLND, which may be mitigated by performing surgery at...
To evaluate population-based survival trends, compared to optimistic trial benchmarks, in metastatic renal cell carcinoma (mRCC). Advances in medical therapy for mRCC may be associated with survival improvements. Yet, targeted therapy trial results focus on patients with favorable-risk mRCC and may not be well disseminated at the population level.Surveillance, Epidemiology, and End Results identified...
To determine the temporal relationship between vasectomy, varicocele, and hypogonadism diagnosis. Many young men undergo their first thorough genitourinary examination in their adult lives at the time of vasectomy consultation, providing a unique opportunity for diagnosis of asymptomatic varicoceles. Varicoceles have recently been implicated as a possible reversible contributor to hypogonadism. Hypogonadism...
Active surveillance is a management plan for localized prostate cancer that offers selective delayed intervention on indication of disease progression, allowing patients to delay or avoid treatment and associated side-effects. Outcomes from centers that promote active surveillance are favorable, with high rates of disease-specific survival. However, there remains a need for prognostic variables or...
It is unclear whether postoperative salvage radiation therapy (SRT) and early adjuvant radiotherapy (ART) after radical prostatectomy lead to equivalent long-term tumor control. We studied a group of patients undergoing ART by comparing them with a matched control group undergoing SRT after biochemical failure.Using a multi-institutional database of 2299 patients, 449 patients with pT3-4N0 disease...
Scrotal malignancies are rare; the published data come from small, single-institution series, with the largest comprising only 28 patients. Using a population-based cancer registry, we describe the demographic and pathologic characteristics of scrotal cancer and report the incidence trends over time.The Surveillance, Epidemiology, and End Results cancer registry was used to identify incident cases...
Primary urethral carcinoma is rare, and the demographic correlates of its incidence have not been examined using population-based data.The National Cancer Institute Surveillance, Epidemiology, and End Results database was used to identify persons diagnosed with primary urethral carcinoma from 1973 to 2002. During this period, the Surveillance, Epidemiology, and End Results program included population-based...
The incidence of testicular cancer in white adults in the United States increased during most of the last half of the 20th century, but information on trends in the occurrence of prepubertal testicular cancer is lacking. We analyzed a population-based cohort to determine whether the incidence trends of prepubertal testicular germ cell tumors have risen similarly to those seen in adult testicular tumors...
A 76-year-old man presented with a painless penile ulcer. After an extensive negative workup, CO 2 laser excision was performed with penile reconstruction. Histologic examination revealed an anaplastic, large cell lymphoma with CD30(+) cells. Computed tomography scans of the thorax, abdomen, and pelvis were negative. He received no adjuvant therapy and was without evidence of recurrence after...
Objectives. To define the serum prostate-specific antigen (PSA) isoform profile in patients who have prostate cancer but do not have a prostate gland, that is, men who have had a previous radical prostatectomy (RP) and subsequently persistent disease as evidenced by elevated PSA. PSA can be reliably measured in the serum in two major isoforms: PSA complexed to alpha 1 -antichymotrypsin and...
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