Search results for: Ken-Ichi Takeyama

Items from 1 to 20 out of 21 results

article

Retraction Notice to: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

Kaoru Yamagata, Sally Fujiyama, Saya Ito, Takashi Ueda, more

Molecular Cell > 2014 > 54 > 3 > 536

article

Retraction: Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD

Masahiko Tanabe, Alexander P. Kouzmenko, Saya Ito, Shun Sawatsubashi, more

Genes to Cells > 18 > 12 > 1147 - 1147

Retraction: The above article in Genes to Cells (doi:10.1111/j.1365‐2443.2008.01244.x), published online on 20 November 2008 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors, the journal Editor in Chief, Mitsuhiro Yanagida, and Wiley Publishing Asia Pty Ltd. The retraction has been agreed to due to inappropriate presentation of gel image for ‘rp49’ that consists of 10 lanes in Figure 3(B). The same gel image with 12 lanes was presented as an outcome of another experiment in the first submitted draft.

article

Retraction: In vivo potentiation of human oestrogen receptor α by Cdk7‐mediated phosphorylation

Saya Ito, Ken‐ichi Takeyama, Ayako Yamamoto, Shun Sawatsubashi, more

Genes to Cells > 18 > 12 > 1144 - 1144

Retraction: The above article in Genes to Cells (doi:10.1111/j.1365‐2443.2004.00777.x), published online on 6 October 2004 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors, the journal Editor in Chief, Mitsuhiro Yanagida, and Wiley Publishing Asia Pty Ltd. The retraction has been agreed to due to multiple usage of the tissue images in Figures 1(B), 2, 3(C), 4 and 6, and the absence of the gel image for the lane 5 of ‘GFP’ in Figure 1(B).

article

Ecdysone receptor (EcR) suppresses lipid accumulation in the Drosophila fat body via transcription control

Yuki Kamoshida, Sally Fujiyama-Nakamura, Shuhei Kimura, Eriko Suzuki, more

Biochemical and Biophysical Research Communications > 2012 > 421 > 2 > 203-207

Lipid metabolism drastically changes in response to the environmental factors in metazoans. Lipid is accumulated at the food rich condition, while mobilized in adipocyte tissue in starvation. Such lipid mobilization is also evident during the pupation of the insects. Pupation is induced by metamorphosis hormone, ecdysone via ecdysone receptor (EcR) with lipid mobilization, however, the molecular link...

article

Epigenetic Silencing of Core Histone Genes by HERS in Drosophila

Saya Ito, Sally Fujiyama-Nakamura, Shuhei Kimura, Jinseon Lim, more

Molecular Cell > 2012 > 45 > 4 > 494-504

Cell cycle-dependent expression of canonical histone proteins enables newly synthesized DNA to be integrated into chromatin in replicating cells. However, the molecular basis of cell cycle-dependency in the switching of histone gene regulation remains to be uncovered. Here, we report the identification and biochemical characterization of a molecular switcher, HERS (histone gene-specific epigenetic...

article

Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

Kaoru Yamagata, Sally Fujiyama, Saya Ito, Takashi Ueda, more

Molecular Cell > 2010 > 37 > 4 > 588

article

Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

Kaoru Yamagata, Sally Fujiyama, Saya Ito, Takashi Ueda, more

Molecular Cell > 2009 > 36 > 2 > 340-347

Steroid hormones and their cognate nuclear receptors exert a wide spectrum of biological actions through regulation of transcriptional and posttranscriptional processes. However, the underlying molecular mechanism by which steroid hormones control posttranscriptional processes is largely unknown. We now report that estrogen receptor alpha (ERα) inhibits the maturation of a particular microRNA (miRNA)...

article

Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor

Shuhei Kimura, Shun Sawatsubashi, Saya Ito, Alexander Kouzmenko, more

Biochemical and Biophysical Research Communications > 2008 > 371 > 4 > 889-893

Histone arginine methylation is an epigenetic marker that regulates gene expression by defining the chromatin state. Arginine methyltransferases, therefore, serve as transcriptional co-regulators. However, unlike other transcriptional co-regulators, the physiological roles of arginine methyltransferases are poorly understood. Drosophila arginine methyltransferase 1 (DART1), the mammalian PRMT1 homologue,...

article

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, more

Molecular Cell > 2008 > 29 > 1 > 92-101

Transcriptional activators, several different coactivators, and general transcription factors are necessary to access specific loci in the dense chromatin structure to allow precise initiation of RNA polymerase II (Pol II) transcription. Histone acetyltransferase (HAT) complexes were implicated in loosening the chromatin around promoters and thus in gene activation. Here we demonstrate that the 2...

article

Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure

Shuhei Kimura, Takahiro Matsumoto, Reiko Matsuyama, Hiroko Shiina, more

Trends in Endocrinology & Metabolism > 2007 > 18 > 5 > 183-189

The action of estrogen in the female reproductive organs is well known in terms of the expression pattern and gene regulation of the estrogen receptor (ER). The significance of ERs in female reproduction is undisputed. The role of the androgen receptor (AR) is less clear. Clinical hyperandrogenism, a typical feature of polycystic ovary syndrome (PCOS), highlights pathological androgen production by...

article

High-Throughput System for Analyzing Ligand-Induced Cofactor Recruitment by Vitamin D Receptor

Midori A. Arai, Ken-ichi Takeyama, Saya Ito, Shigeaki Kato, more

Bioconjugate Chemistry > 2007 > 18 > 3 > 614 - 620

article

Culture serum-induced conversion from agonist to antagonist of a Vitamin D analog, TEI-9647

Kazuyoshi Yamaoka, Mi-sun Kim, Ichiro Takada, Ken-ichi Takeyama, more

Journal of Steroid Biochemistry and Molecular Biology > 2006 > 100 > 4-5 > 177-183

The nuclear receptor for Vitamin D (VDR) mediates many of the effects of Vitamin D in target tissues by regulating gene expression. The transactivation function of ligand-bound VDR in target tissues is thought to depend on the tissue-type and the cellular-environment, but the molecular basis for these differences has not been fully understood. In this study, during characterization of TEI-9647 as...

article

Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation

Shun Sawatsubashi, Akio Maki, Saya Ito, Yuko Shirode, more

Biochemical and Biophysical Research Communications > 2004 > 320 > 1 > 268-272

While the ecdysone dependency of puff formation in giant polytene chromosomes from fly salivary glands has been well documented, the molecular mechanisms underlying this process remain unknown. However, it does appear to involve chromatin remodeling and modification mediated by ecdysone receptor (EcR). As Drosophila poly(ADP-ribose) polymerase (dPARP) has recently been reported to be involved in ecdysone-induced...

article

Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers

Akio Maki, Shun Sawatsubashi, Saya Ito, Yuko Shirode, more

Biochemical and Biophysical Research Communications > 2004 > 320 > 1 > 262-267

Insect development is controlled by the combined actions of ecdysteroid and juvenile hormones. Transcriptional control by ecdysteroid hormones is mediated via two nuclear receptor superfamily members, ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle (USP). Although the ecdysteroid hormone 20-hydroxyecdysone acts as an EcR ligand and activates transcription through EcR/USP heterodimers,...

article

Function of androgen receptor in gene regulations

Shigeaki Kato, Takahiro Matsumoto, Hirotaka Kawano, Takashi Sato, more

Journal of Steroid Biochemistry and Molecular Biology > 2004 > 89-90 > Complete > 627-633

Most of the androgen actions are considered to be mediated by the androgen receptor (AR) of the target genes. The AR is composed of a fairly large molecule because of the long A/B domains of its N-terminal. However, the independent roles of the AR as well as those of the estrogen receptors largely remained unknown mainly due to the lack of the AR knockout (ARKO) mice line. We have succeeded in generating...

article

Androgen receptor functions from reverse genetic models

Takahiro Matsumoto, Ken-ichi Takeyama, Takashi Sato, Shigeaki Kato

Journal of Steroid Biochemistry and Molecular Biology > 2003 > 85 > 2-5 > 95-99

The androgen receptor (AR) is a ligand-dependent transcription factor involved in the regulation of many different physiological processes. AR dysfunction causes a diverse range of clinical conditions, including testicular feminization mutation (Tfm) syndrome, prostate cancer, and motor neuron disease (Kennedy's disease). However, due to lack of genetic models, the molecular basis of the AR in these...

article

Androgen-Dependent Neurodegeneration by Polyglutamine-Expanded Human Androgen Receptor in Drosophila

Ken-ichi Takeyama, Saya Ito, Ayako Yamamoto, Hiromu Tanimoto, more

Neuron > 2002 > 35 > 5 > 855-864

Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset, neurodegenerative disorder affecting only males and is caused by expanded polyglutamine (polyQ) stretches in the N-terminal A/B domain of human androgen receptor (hAR). Although no overt phenotype was detected in adult fly eye photoreceptor neurons expressing mutant hAR (polyQ 52), ingestion of androgen or its known antagonists...

article

In vivo function of VDR in gene expression-VDR knock-out mice

Shigeaki Kato, Ken-ichi Takeyama, Sachiko Kitanaka, Akiko Murayama, more

Journal of Steroid Biochemistry and Molecular Biology > 1999 > 69 > 1-6 > 247-251

Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression. The transactivation function of VDR is activated by binding 1α,25-dihydroxyvitamin D ₃ [1α,25(OH) ₂ D ₃ ], an active form of vitamin D. Conversion from 25(OH)D ₃ is finely regulated in kidney by 25(OH)D ₃ 1α-hydroxylase[25(OH)D 1α-hydroxylase], keeping...

article

The Promoter of the Human 25-Hydroxyvitamin D ₃ 1α-Hydroxylase Gene Confers Positive and Negative Responsiveness to PTH, Calcitonin, and 1α,25(OH) ₂ D ₃

Akiko Murayama, Ken-ichi Takeyama, Sachiko Kitanaka, Yasuo Kodera, more

Biochemical and Biophysical Research Communications > 1998 > 249 > 1 > 11-16

25-Hydroxyvitamin D ₃ 1α-hydroxylase (1α-hydroxylase) catalyzes hydroxylation, mainly in the kidney, of 25-hydroxyvitamin D ₃ [25(OH)D ₃ ] into 1α,25-dihydroxyvitamin D ₃ [1α,25(OH) ₂ D ₃ ], a hormonal form of vitamin D, acting as a key enzyme of vitamin D biosynthesis. Reflecting its biological significance, this enzymatic activity is differentially...

article

Rapid Activation of MAP Kinase by Estrogen in the Bone Cell Line

Hideki Endoh, Haruna Sasaki, Kazunori Maruyama, Ken-ichi Takeyama, more

Biochemical and Biophysical Research Communications > 1997 > 235 > 1 > 99-102

We examined the effect of estrogen on mitogen-activated protein kinase (MAPK) in osteoblastic cells. Rat ROS 17/2.8 cells were exposed to 17β-estradiol (E ₂ ) and MAPK activity in the cells was measured by anin vitrophosphorylation assay. E ₂ treatment caused a rapid and transient MAPK activation within 5 min. Insulin-like growth factor-I, which acts via their membrane receptors, caused...

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Keywords

ECDYSONE RECEPTOR (4)
TRANSCRIPTION (3)
CO-ACTIVATOR (2)
DROSOPHILA MELANOGASTER (2)
ANDROGEN (1)
ANDROGEN RECEPTOR (1)
ANDROGEN RECEPTOR (AR) (1)
ANDROGEN RECEPTOR KNOCKOUT MOUSE (ARKO) (1)
ARGININE METHYLTRANSFERASE (1)
CHROMATIN (1)
CO-REPRESSOR (1)
COFACTOR (1)
CRE-LOXP SYSTEM (1)
DART1 (1)
DNA (1)
DROSOPHILA-EYE MODEL (1)
FAT BODY (1)
HISTONE MODIFICATION (1)
JUVENILE HORMONE III (1)
KENNEDY'S DISEASE (1)
KO MICE (1)
LIGAND (1)
LIPID METABOLISM (1)
METAMORPHOSIS (1)
POLY(ADP-RIBOSE) POLYMERASE (1)
POLY(ADP-RIBOSYL)ATION (1)
POLYQ REPEAT (1)
PROTEINS (1)
PUFF (1)
RNA (1)
SIGNALING (1)
STRUCTURAL ALTERATION (1)
TESTICULAR FEMINIZATION MUTATION (TFM) (1)
TISSUE-SPECIFICITY (1)
TRANSGENIC FLY (1)
ULTRASPIRACLE (1)
VITAMIN D RECEPTOR (1)
more

Data set

Elsevier (18)
Wiley (2)
ACS (1)

Journal

Biochemical and Biophysical Research Communications (7)
Molecular Cell (5)
Journal of Steroid Biochemistry and Molecular Biology (4)
Genes to Cells (2)
Bioconjugate Chemistry (1)
Neuron (1)
Trends in Endocrinology & Metabolism (1)

INFONA - science communication portal

Search results for: Ken-Ichi Takeyama

Retraction Notice to: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

Retraction: Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD

Retraction: In vivo potentiation of human oestrogen receptor α by Cdk7‐mediated phosphorylation

Ecdysone receptor (EcR) suppresses lipid accumulation in the Drosophila fat body via transcription control

Epigenetic Silencing of Core Histone Genes by HERS in Drosophila

Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor

Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure

High-Throughput System for Analyzing Ligand-Induced Cofactor Recruitment by Vitamin D Receptor

Culture serum-induced conversion from agonist to antagonist of a Vitamin D analog, TEI-9647

Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation

Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers

Function of androgen receptor in gene regulations

Androgen receptor functions from reverse genetic models

Androgen-Dependent Neurodegeneration by Polyglutamine-Expanded Human Androgen Receptor in Drosophila

In vivo function of VDR in gene expression-VDR knock-out mice

The Promoter of the Human 25-Hydroxyvitamin D ₃ 1α-Hydroxylase Gene Confers Positive and Negative Responsiveness to PTH, Calcitonin, and 1α,25(OH) ₂ D ₃

Rapid Activation of MAP Kinase by Estrogen in the Bone Cell Line

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