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The aim of this study was to evaluate the usefulness of a computer-aided diagnosis (CAD) system on radiologists' performance for distinction between benign and malignant pulmonary nodules on digital chest radiographs using temporal subtraction images. Fifty-one chest radiographs including 26 malignant nodules and 25 benign nodules were used. The nodule on subtraction image was segmented by thresholding...
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