Search results for: Eva Vlčková

Items from 1 to 9 out of 9 results

article

Continuum of sensory profiles in diabetes mellitus patients with and without neuropathy and pain

Jana Raputova, Aneta Rajdova, Jan Vollert, Iva Srotova, more

European Journal of Pain > 26 > 10 > 2198 - 2212

Background Quantitative sensory testing (QST) assesses the functional integrity of small and large nerve fibre afferents and central somatosensory pathways; QST was assumed to provide insight into the mechanisms of neuropathy. We analysed QST profiles and phenotypes in patients with diabetes mellitus to study whether these could differentiate patients with and without pain and neuropathy. Methods...

article

Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross‐sectional study

David Kec, Aneta Rajdova, Jana Raputova, Blanka Adamova, more

European Journal of Pain > 26 > 2 > 370 - 389

Background Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) and other diabetes mellitus (DM) sufferers is limited. Methods This observational multicentre cohort study employed the Hospital Anxiety and Depression Scale, the Beck Depression Inventory II and the State‐Trait...

article

Diffusion magnetic resonance imaging reveals tract‐specific microstructural correlates of electrophysiological impairments in non‐myelopathic and myelopathic spinal cord compression

Jan Valošek, René Labounek, Tomáš Horák, Magda Horáková, more

European Journal of Neurology > 28 > 11 > 3784 - 3797

Background and purpose Non‐myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible degenerative cervical myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) and electrophysiological measures assess compression severity and neurological dysfunction, respectively, underlying microstructural...

article

Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis

Iva Srotova, Jan Kocica, Jan Vollert, Jan Kolcava, more

European Journal of Pain > 25 > 3 > 573 - 594

Background Central neuropathic extremity pain (CNEP) is the most frequent type of pain in multiple sclerosis (MS). The aim of the present study was to evaluate sensory and pain modulation profiles in MS patients with CNEP. Methods In a single‐centre observational study, a group of 56 CNEP MS patients was compared with 63 pain‐free MS patients and with a sex‐ and age‐adjusted control group. Standardized...

article

Small‐nerve‐fiber pathology in critical illness documented by serial skin biopsies

Miroslav Skorna, Roman Kopacik, Eva Vlckova, Blanka Adamova, more

Muscle & Nerve > 52 > 1 > 28 - 33

Introduction: Small‐fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal nerve fiber density (IENFD) in the distal leg was assessed on admission to the intensive care...

article

Prediabetes/early diabetes‐associated neuropathy predominantly involves sensory small fibres

Sarka Divisova, Eva Vlckova, Maria Hnojcikova, Miroslav Skorna, more

Journal of the Peripheral Nervous System > 17 > 3 > 341 - 350

The aim of this study was to investigate the characteristics of prediabetes (preDM) and early (<3 years) diabetes mellitus type 2 (eDM2)‐associated neuropathy and the value of recently proposed diagnostic criteria for diabetic sensorimotor polyneuropathy (DSPN). A prospective case‐control study in a group of 48 consecutive patients with eDM2, 16 preDM patients and 40 age‐ and sex‐matched normoglycaemic...

article

Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations

Petra Praksova, Pavel Stourac, Josef Bednarik, Eva Vlckova, more

Journal of the Neurological Sciences > 2012 > 319 > 1-2 > 18-23

Multiple sclerosis (MS) is a chronic disease characterized by demyelination and chronic inflammation of the central nervous system (CNS). Many of the immune cells including T and B cells seem to be involved in disease pathogenesis by inducing or controlling the immune responses in the nervous system of MS patients. The objective of this study was to evaluate the differences in subpopulations of T...

article

Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus

Sarka Bursova, Petr Dubovy, Eva Vlckova-Moravcova, Martin Nemec, more

Journal of the Neurological Sciences > 2012 > 315 > 1-2 > 60-63

The growth-associated protein 43 (GAP-43) is known as a marker of regenerating nerve fibers and their continuous remodeling in the adult human skin. The purpose of this pilot study was to investigate a possible role for GAP-43 in the detection of the early stages of small-fiber neuropathy in patients with type 2 diabetes mellitus (DM2) as compared with a well- established and validated parameter –...

article

Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities

Andrea Scherens, Christoph Maier, Ida Sybille Haussleiter, Peter Schwenkreis, more

European Journal of Pain > 2009 > 13 > 7 > 711-718

Dysesthesias of the lower limbs are a common complaint of patients and may be indicative of peripheral neuropathy. Here we investigated the prevalence and type of neuropathy in patients presenting with this complaint and compared the diagnostic performance of different diagnostic modalities. Forty-two patients were recruited prospectively and underwent a clinical examination, nerve conduction studies,...

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