Search results for: Alan G. Marshall

Items from 1 to 20 out of 298 results

article

A PERSONAL SCIENTIFIC HISTORY

Alan G. Marshall

Mass Spectrometry Reviews > 41 > 2 > 243 - 247

article

Middle‐Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms

Tingting Jiang, Michael E. Hoover, Matthew V. Holt, Michael A. Freitas, more

PROTEOMICS > 18 > 11 > n/a - n/a

Post‐translational modifications (PTMs) of histones are important epigenetic regulatory mechanisms that are often dysregulated in cancer. We employ middle‐down proteomics to investigate the PTMs and proteoforms of histone H4 during cell cycle progression. We use pH gradient weak cation exchange‐hydrophilic interaction liquid chromatography (WCX‐HILIC) for on‐line liquid chromatography‐mass spectrometry...

article

Pih1p-Tah1p Puts a Lid on Hexameric AAA+ ATPases Rvb1/2p

Shaoxiong Tian, Ge Yu, Huan He, Yu Zhao, more

Structure > 2017 > 25 > 10 > 1519-1529.e4

The Saccharomyces cerevisiae (Sc) R2TP complex affords an Hsp90-mediated and nucleotide-driven chaperone activity to proteins of small ribonucleoprotein particles (snoRNPs). The current lack of structural information on the ScR2TP complex, however, prevents a mechanistic understanding of this biological process. We characterized the structure of the ScR2TP complex made up of two AAA+ ATPases, Rvb1/2p,...

article

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Chad R. Weisbrod, Nathan K. Kaiser, John E. P. Syka, Lee Early, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 9 > 1787-1795

High resolution mass spectrometry is a key technology for in-depth protein characterization. High-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) enables high-level interrogation of intact proteins in the most detail to date. However, an appropriate complement of fragmentation technologies must be paired with FTMS to provide comprehensive sequence coverage, as well as...

article

Erratum to: Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Lidong He, Lissa C. Anderson, David R. Barnidge, David L. Murray, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 839-839

The online version of the original article can be found at http://dx.doi.org/10.1007/s13361-017-1602-6

article

Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Lidong He, Lissa C. Anderson, David R. Barnidge, David L. Murray, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 827-838

With the rapid growth of therapeutic monoclonal antibodies (mAbs), stringent quality control is needed to ensure clinical safety and efficacy. Monoclonal antibody primary sequence and post-translational modifications (PTM) are conventionally analyzed with labor-intensive, bottom-up tandem mass spectrometry (MS/MS), which is limited by incomplete peptide sequence coverage and introduction of artifacts...

article

Ultrahigh‐resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo amino acid sequencing for a seven‐protein mixture by paired single‐residue transposed Lys‐N and Lys‐C digestion

Xiaoyan Guan, Naomi C. Brownstein, Nicolas L. Young, Alan G. Marshall

Rapid Communications in Mass Spectrometry > 31 > 2 > 207 - 217

Rationale Bottom‐up tandem mass spectrometry (MS/MS) is regularly used in proteomics to identify proteins from a sequence database. De novo sequencing is also available for sequencing peptides with relatively short sequence lengths. We recently showed that paired Lys‐C and Lys‐N proteases produce peptides of identical mass and similar retention time, but different tandem mass spectra. Such parallel...

article

An ultrahigh‐resolution mass spectrometry index to estimate natural organic matter lability

Juliana D'Andrilli, William T. Cooper, Christine M. Foreman, Alan G. Marshall

Rapid Communications in Mass Spectrometry > 29 > 24 > 2385 - 2401

RationaleDetermining the chemical constituents of natural organic matter (NOM) by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICRMS) remains the ultimate measure for probing its source material, evolution, and transport; however, lability and the fate of organic matter (OM) in the environment remain controversial. FTICRMS‐derived elemental compositions are presented in this study...

article

Paired single residue‐transposed Lys‐N and Lys‐C digestions for label‐free identification of N‐terminal and C‐terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing

Naomi C. Brownstein, Xiaoyan Guan, Yuan Mao, Qian Zhang, more

Rapid Communications in Mass Spectrometry > 29 > 7 > 659 - 666

RATIONALEPaired Lys‐N and Lys‐C proteases produce peptides of identical mass and similar retention time, but different tandem mass spectra. Data from these parallel experiments provide constraints that are applied before data analysis. With this approach, we can find matched spectra before analysis, distinguish ion type, and determine residue level confidence. METHODSAliquots are digested separately...

article

Epitope mapping of 7S cashew antigen in complex with antibody by solution‐phase H/D exchange monitored by FT‐ICR mass spectrometry

Xiaoyan Guan, Kyle A. Noble, Yeqing Tao, Kenneth H. Roux, more

Journal of Mass Spectrometry > 50 > 6 > 812 - 819

The potential epitope of a recombinant food allergen protein, cashew Ana o 1, reactive to monoclonal antibody, mAb 2G4, has been mapped by solution‐phase amide backbone H/D exchange (HDX) monitored by Fourier transform ion cyclotron resonance mass spectrometry (FT‐ICR MS). Purified mAb 2G4 was incubated with recombinant Ana o 1 (rAna o 1) to form antigen:monoclonal antibody (Ag:mAb) complexes. Complexed...

article

DART Fourier transform ion cyclotron resonance mass spectrometry for analysis of complex organic mixtures

Vladislav V. Lobodin, Leonard Nyadong, Brian M. Ruddy, Matthew Curtis, more

International Journal of Mass Spectrometry > 2015 > 378 > C > 186-192

We report the first combination of a commercial direct analysis in real time (DART) source with FT-ICR MS and its application to analysis of complex organic mixtures. DART enables ionization of compounds with little or no sample preparation, and FT-ICR provides ultrahigh mass resolution and mass accuracy. The combination provides a rapid, robust, and reliable method for analysis of components spanning...

article

40 years of Fourier transform ion cyclotron resonance mass spectrometry

Alan G. Marshall, Tong Chen

International Journal of Mass Spectrometry > 2015 > 377 > C > 410-420

This article reviews the development of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) in several respects: (a) a strong static magnetic field serves to convert ion mass-to-charge ratio into cyclotron frequency. Because frequency is the most accurately measurable property, ICR MS inherently offers higher mass resolution and mass accuracy than any other mass analyzer. (b) Coherent...

article

Improved ion optics for introduction of ions into a 9.4‐T Fourier transform ion cyclotron resonance mass spectrometer

Yu Chen, Franklin E. Leach, Nathan K. Kaiser, Xibei Dang, more

Journal of Mass Spectrometry > 50 > 1 > 280 - 284

Enhancements to the ion source and transfer optics of our 9.4 T Fourier transform ion cyclotron resonance (ICR) mass spectrometer have resulted in improved ion transmission efficiency for more sensitive mass measurement of complex mixtures at the MS and MS/MS levels. The tube lens/skimmer has been replaced by a dual ion funnel and the following octopole by a quadrupole for reduced ion cloud radial...

article

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Christopher L. Hendrickson, John P. Quinn, Nathan K. Kaiser, Donald F. Smith, more

Journal of The American Society for Mass Spectrometry > 2015 > 26 > 9 > 1626-1632

We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front...

article

Longitudinal shifts in dissolved organic matter chemogeography and chemodiversity within headwater streams: a river continuum reprise

Jennifer J. Mosher, Louis A. Kaplan, David C. Podgorski, Amy M. McKenna, more

Biogeochemistry > 2015 > 124 > 1-3 > 371-385

We tested a long-standing hypothesis within river ecology, predicted by the River Continuum Concept, that dissolved organic matter (DOM) diversity decreases with stream order. We measured DOM molecular composition across three stream orders in the headwaters of well characterized forested catchments with ultrahigh-resolution mass spectrometry to assess DOM chemogeography and chemodiversity over the...

article

Protected Amine Labels: A Versatile Molecular Scaffold for Multiplexed Nominal Mass and Sub-Da Isotopologue Quantitative Proteomic Reagents

Scott B. Ficarro, Jessica M. Biagi, Jinhua Wang, Jenna Scotcher, more

Journal of The American Society for Mass Spectrometry > 2014 > 25 > 4 > 636-650

We assemble a versatile molecular scaffold from simple building blocks to create binary and multiplexed stable isotope reagents for quantitative mass spectrometry. Termed Protected Amine Labels (PAL), these reagents offer multiple analytical figures of merit including, (1) robust targeting of peptide N-termini and lysyl side chains, (2) optimal mass spectrometry ionization efficiency through regeneration...

article

Characterization of IHSS Pony Lake fulvic acid dissolved organic matter by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and fluorescence spectroscopy

Juliana D’Andrilli, Christine M. Foreman, Alan G. Marshall, Diane M. McKnight

Organic Geochemistry > 2013 > 65 > Complete > 19-28

We present the extensive characterization of Antarctic Pony Lake (PL) dissolved organic matter (DOM), an International Humic Substance Society (IHSS) fulvic acid (FA) reference standard, using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) and excitation–emission matrix fluorescence spectroscopy (EEMS). PLFA is the first reference standard available...

article

Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription

Yifat Ofir-Birin, Pengfei Fang, Steven P. Bennett, Hui-Min Zhang, more

Molecular Cell > 2013 > 49 > 1 > 30-42

Lysyl-tRNA synthetase (LysRS), a component of the translation apparatus, is released from the cytoplasmic multi-tRNA synthetase complex (MSC) to activate the transcription factor MITF in stimulated mast cells through undefined mechanisms. Here we show that Ser207 phosphorylation provokes a new conformer of LysRS that inactivates its translational function but activates its transcriptional function...

article

Laserspray and Matrix-Assisted Ionization Inlet Coupled to High-Field FT-ICR Mass Spectrometry for Peptide and Protein Analysis

Leonard Nyadong, Ellen D. Inutan, Xu Wang, Christopher L. Hendrickson, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 3 > 320-328

We present the first coupling of laser spray ionization inlet (LSII) and matrix assisted ionization inlet (MAII) to high-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for generation of electrospray-like ions to take advantage of increased sensitivity, mass range, and mass resolving power afforded by multiple charging. We apply the technique to top-down protein analysis...

article

Rapid Screening for Potential Epitopes Reactive with a Polycolonal Antibody by Solution-Phase H/D Exchange Monitored by FT-ICR Mass Spectrometry

Qian Zhang, Kyle A. Noble, Yuan Mao, Nicolas L. Young, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 7 > 1016-1025

The potential epitopes of a recombinant food allergen protein, cashew Ana o 2, reactive to polyclonal antibodies, were mapped by solution-phase amide backbone H/D exchange (HDX) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Ana o 2 polyclonal antibodies were purified in the serum from a goat immunized with cashew nut extract. Antibodies were incubated with recombinant...

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Data set

ACS (111)
Elsevier (109)
Springer (66)
Wiley (12)

Journal

Journal of The American Society for Mass Spectrometry (61)
Analytical Chemistry (48)
Journal of the American Society for Mass Spectrometry (48)
Energy & Fuels (34)
International Journal of Mass Spectrometry (27)
Rapid Communications in Mass Spectrometry (7)
Journal of Proteome Research (6)
Organic Geochemistry (6)
International Journal of Mass Spectrometry and Ion Processes (5)
The Journal of Physical Chemistry A (4)
The Journal of Physical Chemistry B (4)
Biochemistry (3)
Biophysical Journal (3)
Chemical Physics Letters (3)
Environmental Science & Technology (3)
Fuel (3)
Journal of Mass Spectrometry (3)
Chemistry of Materials (2)
Journal of Agricultural and Food Chemistry (2)
Journal of Molecular Biology (2)
Marine Chemistry (2)
Accounts of Chemical Research (1)
Analytical and Bioanalytical Chemistry (1)
Archives of Biochemistry and Biophysics (1)
BBA - Proteins and Proteomics (1)
Biochemical and Biophysical Research Communications (1)
Biogeochemistry (1)
Glycoconjugate Journal (1)
Inorganic Chemistry (1)
Journal of Chromatography A (1)
Journal of Chromatography B (1)
Journal of Cluster Science (1)
Journal of the American Chemical Society (1)
Mass Spectrometry Reviews (1)
Molecular Cell (1)
Nuclear Inst. and Methods in Physics Research, A (1)
Organic Letters (1)
Organometallics (1)
PROTEOMICS (1)
Physica B: Physics of Condensed Matter (1)
Protein Expression and Purification (1)
Structure (1)
Virology (1)
more

INFONA - science communication portal

Search results for: Alan G. Marshall

A PERSONAL SCIENTIFIC HISTORY

Middle‐Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms

Pih1p-Tah1p Puts a Lid on Hexameric AAA+ ATPases Rvb1/2p

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Erratum to: Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Ultrahigh‐resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo amino acid sequencing for a seven‐protein mixture by paired single‐residue transposed Lys‐N and Lys‐C digestion

An ultrahigh‐resolution mass spectrometry index to estimate natural organic matter lability

Paired single residue‐transposed Lys‐N and Lys‐C digestions for label‐free identification of N‐terminal and C‐terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing

Epitope mapping of 7S cashew antigen in complex with antibody by solution‐phase H/D exchange monitored by FT‐ICR mass spectrometry

DART Fourier transform ion cyclotron resonance mass spectrometry for analysis of complex organic mixtures

40 years of Fourier transform ion cyclotron resonance mass spectrometry

Improved ion optics for introduction of ions into a 9.4‐T Fourier transform ion cyclotron resonance mass spectrometer

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Longitudinal shifts in dissolved organic matter chemogeography and chemodiversity within headwater streams: a river continuum reprise

Protected Amine Labels: A Versatile Molecular Scaffold for Multiplexed Nominal Mass and Sub-Da Isotopologue Quantitative Proteomic Reagents

Characterization of IHSS Pony Lake fulvic acid dissolved organic matter by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and fluorescence spectroscopy

Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription

Laserspray and Matrix-Assisted Ionization Inlet Coupled to High-Field FT-ICR Mass Spectrometry for Peptide and Protein Analysis

Rapid Screening for Potential Epitopes Reactive with a Polycolonal Antibody by Solution-Phase H/D Exchange Monitored by FT-ICR Mass Spectrometry

Filter options

Publication date

Content availability

Publication language

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Alan G. Marshall

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication language

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options