Search results for: Edit I. Buzás

Items from 1 to 20 out of 27 results

article

Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment

Tamás G. Gergely, Dániel Kucsera, Viktória E. Tóth, Tamás Kovács, more

British Journal of Pharmacology > 180 > 6 > 740 - 761

Background and Purpose Immune checkpoint inhibitors (ICI), such as anti‐PD‐1 monoclonal antibodies, have revolutionized cancer therapy by enhancing the cytotoxic effects of T‐cells against tumours. However, enhanced T‐cell activity also may cause myocarditis and cardiotoxicity. Our understanding of the mechanisms of ICI‐induced cardiotoxicity is limited. Here, we aimed to investigate the effect of...

article

Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors

Zsuzsanna Szvicsek, Ádám Oszvald, Lili Szabó, Gyöngyvér Orsolya Sándor, more

Cellular and Molecular Life Sciences > 2019 > 76 > 12 > 2463-2476

Extracellular vesicles (EVs) are membrane-surrounded structures that transmit biologically important molecules from the releasing to target cells, thus providing a novel intercellular communication mechanism. Since EVs carry their cargo in a protected form and their secretion is generally increased in tumorigenesis, EVs hold a great potential for early cancer diagnosis. By 3D culturing, we provide...

article

Skin‐homing CD8⁺ T cells preferentially express GPI‐anchored peptidase inhibitor 16, an inhibitor of cathepsin K

Nikolett Lupsa, Barbara Érsek, Andor Horváth, András Bencsik, more

European Journal of Immunology > 48 > 12 > 1944 - 1957

This study sought to identify novel CD8⁺ T cell homing markers by studying acute graft versus host disease (aGvHD), typically involving increased T cell homing to the skin and gut. FACS‐sorted skin‐homing (CD8β⁺/CLA⁺), gut‐homing (CD8β⁺/integrinβ7⁺), and reference (CD8β⁺/CLA^–/integrinβ7^–) T cells were compared in patients affected by cutaneous and/or gastrointestinal aGVHD. Microarray analysis, qPCR,...

article

Molecular interactions at the surface of extracellular vesicles

Edit I. Buzás, Eszter Á. Tóth, Barbara W. Sódar, Katalin É. Szabó-Taylor

Seminars in Immunopathology > 2018 > 40 > 5 > 453-464

Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine. One of the key features of extracellular vesicles is that they have relatively large surface compared to their volume. Some extracellular vesicle...

article

Mast cell secretome: Soluble and vesicular components

Krisztina V. Vukman, András Försönits, Ádám Oszvald, Eszter Á. Tóth, more

Seminars in Cell & Developmental Biology > 2017 > 67 > C > 65-73

Mast cells are multifunctional master cells implicated in both innate and adaptive immune responses. Their role has been best characterized in allergy and anaphylaxis; however, emerging evidences support their contribution to a wide variety of human diseases.Mast cells, being capable of both degranulation and subsequent recovery, have recently attracted substantial attention as also being rich sources...

article

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Nikolett Marton, Orsolya Tünde Kovács, Eszter Baricza, Ágnes Kittel, more

Cellular and Molecular Life Sciences > 2017 > 74 > 19 > 3599-3611

Objective Extracellular vesicles (EVs) are subcellular signalosomes. Although characteristic EV production is associated with numerous physiological and pathological conditions, the effect of blood-derived EVs on bone homeostasis is unknown. Herein we evaluated the role of circulating EVs on human osteoclastogenesis. Methods Blood samples from healthy volunteers, rheumatoid arthritis (RA) and psoriatic...

article

Unique patterns of CD8+ T-cell-mediated organ damage in the Act-mOVA/OT-I model of acute graft-versus-host disease

Barbara Érsek, Nikolett Lupsa, Péter Pócza, Anett Tóth, more

Cellular and Molecular Life Sciences > 2016 > 73 > 20 > 3935-3947

T-cell receptor (TCR)-transgenic models of acute graft-versus-host disease (aGvHD) offer a straightforward and highly controlled approach to study the mechanisms and consequences of T-cell activation following allogeneic hematopoietic stem cell transplantation (aHSCT). Here, we report that aHSCT involving OT-I mice as donors, carrying an ovalbumin-specific CD8+ TCR, and Act-mOVA mice as recipients,...

article

The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells

Eszter Baricza, Viola Tamási, Nikolett Marton, Edit I. Buzás, more

Cellular and Molecular Life Sciences > 2016 > 73 > 1 > 95-117

The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor, which plays an essential role in the xenobiotic metabolism in a wide variety of cells. The AHR gene is evolutionarily conserved and it has a central role not only in the differentiation and maturation of many tissues, but also in the toxicological metabolism of the cell by the activation of metabolizing enzymes. Several lines...

article

Mass spectrometry of extracellular vesicles

Gabriella Pocsfalvi, Christopher Stanly, Annalisa Vilasi, Immacolata Fiume, more

Mass Spectrometry Reviews > 35 > 1 > 3 - 21

The review briefly summaries main features of extracellular vesicles, a joint terminology for exosomes, microvesicles, and apoptotic vesicles. These vesicles are in the center of interest in biology and medical sciences, and form a very active field of research. Mass spectrometry (MS), with its specificity and sensitivity, has the potential to identify and characterize molecular composition of these...

article

Protein Tyrosine Phosphatase Nonreceptor Type 2: An Important Regulator of lnterleukin‐6 Production in Rheumatoid Arthritis Synovial Fibroblasts

Borbala Aradi, Masaru Kato, Maria Filkova, Emmanuel Karouzakis, more

Arthritis & Rheumatology > 67 > 10 > 2624 - 2633

Objective To investigate the role of protein tyrosine phosphatase nonreceptor type 2 (PTPN2) in the pathogenesis of rheumatoid arthritis (RA). Methods Synovial tissue samples from patients with RA and patients with osteoarthritis (OA) were stained for PTPN2. Synovial fibroblasts were stimulated with tumor necrosis factor (TNF) and interleukin‐1β (IL‐1β), lipopolysaccharide (LPS), TRAIL, or thapsigargin...

article

Oxidative and other posttranslational modifications in extracellular vesicle biology

Katalin Szabó-Taylor, Brent Ryan, Xabier Osteikoetxea, Tamás G. Szabó, more

Seminars in Cell and Developmental Biology > 2015 > 40 > Complete > 8-16

Extracellular vesicles including exosomes, microvesicles and apoptotic vesicles, are phospholipid bilayer surrounded structures secreted by cells universally, in an evolutionarily conserved fashion. Posttranslational modifications such as oxidation, citrullination, phosphorylation and glycosylation play diverse roles in extracellular vesicle biology. Posttranslational modifications orchestrate the...

article

Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics

Dora Melicher, Edit I. Buzas, Andras Falus

Cellular and Molecular Life Sciences > 2015 > 72 > 21 > 4095-4109

Telomeres are protective heterochromatic structures that cap the end of linear chromosomes and play a key role in preserving genomic stability. Telomere length represents a balance between processes that shorten telomeres during cell divisions with incomplete DNA replication and the ones that lengthen telomeres by the action of telomerase, an RNA–protein complex with reverse transcriptase activity...

article

Immunosuppressants increase the levels of natural autoantibodies reactive with glycosaminoglycans in myasthenia gravis

Zsuzsanna Pal, László Tóthfalusi, Zsolt Lörincz, Bence György, more

Journal of Neuroimmunology > 2014 > 276 > 1-2 > 224-228

Increasing number of evidences support the role of glycosylation in the evolution of autoimmunity. We examined carbohydrate-reactive natural autoantibodies systematically for the first time in patients with autoimmune myasthenia gravis.Antibodies reactive to glycosaminoglycans were measured with CovaLink ELISA in the sera of 59 myasthenia patients as well as in 54 healthy controls. We used the GlycoChip...

article

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Zoltán Giricz, Zoltán V. Varga, Tamás Baranyai, Péter Sipos, more

Journal of Molecular and Cellular Cardiology > 2014 > 68 > Complete > 75-78

Remote ischemic preconditioning (RIPC) of the heart is exerted by brief ischemic insults affected on a remote organ or a remote area of the heart before a sustained cardiac ischemia. To date, little is known about the inter-organ transfer mechanisms of cardioprotection by RIPC. Exosomes and microvesicles/microparticles are vesicles of 30–100nm and 100–1000nm in diameter, respectively (collectively...

article

Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube

Bence György, Krisztina Pálóczi, Alexandra Kovács, Eszter Barabás, more

Thrombosis Research > 2014 > 133 > 2 > 285-292

Recently extracellular vesicles (exosomes, microparticles also referred to as microvesicles and apoptotic bodies) have attracted substantial interest as potential biomarkers and therapeutic vehicles. However, analysis of microparticles in biological fluids is confounded by many factors such as the activation of cells in the blood collection tube that leads to in vitro vesiculation. In this study we...

article

Antitumoral effects of 9-cis retinoic acid in adrenocortical cancer

Diana Rita Szabó, Kornélia Baghy, Peter M. Szabó, Adrienn Zsippai, more

Cellular and Molecular Life Sciences > 2014 > 71 > 5 > 917-932

The currently available medical treatment options of adrenocortical cancer (ACC) are limited. In our previous meta-analysis of adrenocortical tumor genomics data, ACC was associated with reduced retinoic acid production and retinoid X receptor-mediated signaling. Our objective has been to study the potential antitumoral effects of 9-cis retinoic acid (9-cisRA) on the ACC cell line NCI-H295R and in...

article

The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis

Petra Misják, Szilvia Bősze, Kata Horváti, Mária Pásztói, more

Immunology Letters > 2013 > 152 > 1 > 25-31

The P70-84 peptide (also called 5/4E8 epitope) of the human cartilage proteoglycan (PG) aggrecan is the dominant/arthritogenic epitope in both humans and arthritis-prone BALB/c mice (PG-induced arthritis, PGIA). An elevated T cell reactivity was demonstrated to a citrullinated version of the P70-84 epitope in most of the patients with rheumatoid arthritis (RA). The goal of this study was to understand...

article

La citrullination en situations normale et pathologique

Zsuzsanna Baka, Bence György, Pál Géher, Edit I. Buzás, more

Revue du rhumatisme > 2013 > 80 > 1 > 18-24

La citrullination, modification enzymatique post-traductionnelle, est un sujet d’actualité très développé récemment en raison de son implication dans divers processus physiologiques et pathologiques. Les anticorps antiprotéines citrullinées constituent des facteurs diagnostiques et pronostiques de la polyarthrite rhumatoïde, et sont spécifiques de cette maladie. La citrullination a un rôle important...

article

Citrullination under physiological and pathological conditions

Zsuzsanna Baka, Bence György, Pál Géher, Edit I. Buzás, more

Joint Bone Spine > 2012 > 79 > 5 > 431-436

Citrullination, one of the enzymatic posttranslational modifications has become a hot topic of recent research as it is involved in various physiological and pathological processes. Antibodies against citrullinated proteins called anti-citrullinated protein antibodies, are the hallmark (diagnostic and prognostic factors) of rheumatoid arthritis, and are specific for the disease. Citrullination has...

article

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

Lilla Turiák, Petra Misják, Tamás G. Szabó, Borbála Aradi, more

Journal of Proteomics > 2011 > 74 > 10 > 2025-2033

Several studies have characterized exosomes derived from different cell sources. In this work we set the goal of proteomic characterization of two less studied populations of membrane vesicles, microvesicles (100–800nm) and apoptotic bodies (>800nm) released by thymus cells of BALB/c mice. The vesicles were isolated by the combination of differential centrifugation and gravity driven multistep...

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Search results for: Edit I. Buzás

Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment

Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors

Skin‐homing CD8⁺ T cells preferentially express GPI‐anchored peptidase inhibitor 16, an inhibitor of cathepsin K

Molecular interactions at the surface of extracellular vesicles

Mast cell secretome: Soluble and vesicular components

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Unique patterns of CD8+ T-cell-mediated organ damage in the Act-mOVA/OT-I model of acute graft-versus-host disease

The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells

Mass spectrometry of extracellular vesicles

Protein Tyrosine Phosphatase Nonreceptor Type 2: An Important Regulator of lnterleukin‐6 Production in Rheumatoid Arthritis Synovial Fibroblasts

Oxidative and other posttranslational modifications in extracellular vesicle biology

Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics

Immunosuppressants increase the levels of natural autoantibodies reactive with glycosaminoglycans in myasthenia gravis

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube

Antitumoral effects of 9-cis retinoic acid in adrenocortical cancer

The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis

La citrullination en situations normale et pathologique

Citrullination under physiological and pathological conditions

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

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