Search results for: Kazunori Toma

Items from 1 to 20 out of 32 results

article

Composition‐dependent sol‐gel transition of amphiphilic blend of PEG with hydrophobic gallamide components

Akihiro Aso, Kazutaka Taki, Tomoki Maeda, Kazunori Toma, more

Journal of Applied Polymer Science > 135 > 24 > n/a - n/a

Two types of poly(ethylene glycol) (PEG)‐based amphiphiles were synthesized: a diblock‐type amphiphile (PEG1) with a hydrophobic moiety on one terminal of PEG (PEG with the molecular weight of 2000), and a triblock‐type amphiphile (PEG2) with hydrophobic moieties on both terminals of PEG. The hydrophobic moiety consisted of hydrophobic C₁₄ alkyl tails covalently linked through a gallamide component...

chapter

Numerical demonstration of deterministic spatiotemporal control of localized plasmon pulses at metallic nanostructures by light wave shaping

Yasuhiro Kojima, Yuta Masaki, Kazunori Toma, Kenichi Hirosawa, more

2015 11th Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) > 3 > 1 - 2

2015 11th Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR)

We numerically demonstrate spatiotemporal control of ultrafast localized plasmon pulses at metallic nanostructures. This results confirm that more flexible spatiotemporal control can be achieved by femtosecond laser pulses combined with wave front and pulse shaping.

chapter

Control of grating-coupled ultrafast surface plasmon pulse and its nonlinear emission by shaping femtosecond laser pulse

Yuta Masaki, Kazunori Toma, Miyuki Kusaba, Kenichi Hirosawa, more

2014 Conference on Lasers and Electro-Optics (CLEO) - Laser Science to Photonic Applications > 1 - 2

2014 Conference on Lasers and Electro-Optics (CLEO)

Spatiotemporal nanofocusing of surface plasmon polariton excited by femtosecond laser pulses on a sharp conical Au tip with a tip edge radius of few tens of nanometers is deterministically controlled.

chapter

Spatiotemporal control of femtosecond plasmon with spectral interferometry NSOM

Kazunori Toma, Shutaro Onishi, Miyuki Kusaba, Kenichi Hirosawa, more

2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEOPR) > 1 - 2

2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR)

Based on a plasmon response function in both amplitude and phase measured by a spectral interferometry combined with a near-field scanning optical microscopy (NSOM), the femtosecond plasmon pulse at gold nanostructures is deterministically tailored.

article

Laminin active peptide/agarose matrices as multifunctional biomaterials for tissue engineering

Yuji Yamada, Kentaro Hozumi, Akihiro Aso, Atsushi Hotta, more

Biomaterials > 2012 > 33 > 16 > 4118-4125

Cell adhesive peptides derived from extracellular matrix components are potential candidates to afford bio-adhesiveness to cell culture scaffolds for tissue engineering. Previously, we covalently conjugated bioactive laminin peptides to polysaccharides, such as chitosan and alginate, and demonstrated their advantages as biomaterials. Here, we prepared functional polysaccharide matrices by mixing laminin...

article

Early entry and deformation of macropinosomes correlates with high efficiency of decaarginine‐polyethylene glycol‐lipid‐mediated gene delivery

Shouhei Kobayashi, Yoshiyuki Hattori, Hiroko Osakada, Kazunori Toma, more

The Journal of Gene Medicine > 14 > 4 > 262 - 271

BackgroundDecaarginine‐polyethylene glycol‐conjugated 3,5‐bis(dodecyloxy)benzamide/plasmid DNA [Arg10‐polyethylene glycol (PEG)‐lipid/plasmid DNA (pDNA)] complexes (designated R10B/DNA complexes) are efficient nonviral carriers for pDNA delivery into human cervical carcinoma HeLa cells. Previous reports indicated that these complexes formed at a relatively low R10B/DNA ratio and showed high transgene...

article

Cell line-dependent internalization pathways determine DNA transfection efficiency of decaarginine-PEG-lipid

Tomohiro Izumisawa, Yoshiyuki Hattori, Masataka Date, Kazunori Toma, more

International Journal of Pharmaceutics > 2011 > 404 > 1-2 > 264-270

Previously, we have reported that decaarginine-conjugated PEG-lipids (R10B) efficiently delivered plasmid DNA (pDNA) into human cervical carcinoma HeLa cells via macropinocytosis; however, the mechanism of cellular uptake by R10B was not evaluated in other cell lines. In this study, we investigated the internalization mechanism by R10B/pDNA complex (R10B-lipoplex) in human prostate tumor PC-3 and...

article

Supramolecular gelation of alcohol and water by synthetic amphiphilic gallic acid derivatives

Hitoshi Tamiaki, Keishiro Ogawa, Keisuke Enomoto, Kazutaka Taki, more

Tetrahedron > 2010 > 66 > 9 > 1661-1666

The supramolecular organogelation of alcohols was observed in relatively hydrophobic amphiphiles with a short oligo(ethylene glycol) unit and three long alkyl chains at room temperature, while the hydrogelation occurred in more hydrophilic gelators with a longer poly(ethylene glycol) unit and two long alkyl chains at various temperatures. When a hot aqueous solution of some of the synthetic hydrogelators...

article

Decaarginine-PEG-liposome enhanced transfection efficiency and function of arginine length and PEG

Masahiko Furuhata, Tomohiro Izumisawa, Hiroko Kawakami, Kazunori Toma, more

International Journal of Pharmaceutics > 2009 > 371 > 1-2 > 40-46

Oligoarginine-conjugated lipids ((Arg)n-PEG-lipid) (n=4, 6, 8, and 10: number of arginine residues) are novel gene delivery vectors. We prepared two oligoarginine-modified liposomes using (Arg)n-lipid without and with poly(ethylene glycol) (PEG) spacer ((Arg)n-L and (Arg)n-PEG-L), and investigated the effect of PEG spacer and oligoarginine length of liposomes on cellular uptake, gene transfection,...

article

Smart pH sensitive luminescent hydrogel based on Eu(III) β-diketonate complex and its enhanced photostability

QianMing Wang, Keishiro Ogawa, Kazunori Toma, Hitoshi Tamiaki

Journal of Photochemistry & Photobiology, A: Chemistry > 2009 > 201 > 2-3 > 87-90

A luminescent hydrogel was successfully prepared by immobilizing an europium(III) tetrakis(β-diketonate) complex into a gallate-based hydrogelator. The Eu(III) emission in hydrogel media was switched reversibly “on-off” as a function of pH and the corresponding thermal and photostabilities dramatically increased compared with its solution sample.

article

High gene delivery in tumor by intratumoral injection of tetraarginine-PEG lipid-coated protamine/DNA

Takashi Fujita, Masahiko Furuhata, Yoshiyuki Hattori, Hiroko Kawakami, more

Journal of Controlled Release > 2008 > 129 > 2 > 124-127

One obstacle to effective gene therapy lies in low transfection efficiency by non-viral vectors. To meet this challenge, we developed cell-penetrating peptide-based gene delivery vectors. A novel oligoarginine lipid ((Arg)n-B, n=4, 10) conjugated to 3,5-bis(dodecyloxy)benzamide (BDB) lipid with a poly(ethylene glycol) (PEG) spacer was synthesized. Oligoarginine lipid-coated vector was prepared by...

article

In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin

Masato Watanabe, Kumi Kawano, Kazunori Toma, Yoshiyuki Hattori, more

Journal of Controlled Release > 2008 > 127 > 3 > 231-238

Camptothecin (CPT) is a strong antitumor agent, but its use limited by its low solubility and the instability of the active lactone form. To overcome these difficulties, liposomes incorporating CPT (CPT liposomes) were designed and tested. CPT liposomes were formulated by the addition of 3,5-bis(dodecyloxy)benzoic acid (DB) to polyethylene glycol-containing liposomes, and by coating the surface of...

article

One-Dimensional Array of Au Nanoparticles Fixed on Nanofibers of Organogelators by the Langmuir−Blodgett Method

Ryo Tsunashima, Shin-ichiro Noro, Tomoyuki Akutagawa, Takayoshi Nakamura, more

The Journal of Physical Chemistry C > 2007 > 111 > 2 > 901 - 907

article

Isolation and Characterization of Phage-Displayed Single Chain Antibodies Recognizing Nonreducing Terminal Mannose Residues. 1. A New Strategy for Generation of Anti-Carbohydrate Antibodies ^†

Keiko Sakai, Yoshitaka Shimizu, Tomoki Chiba, Ayano Matsumoto-Takasaki, more

Biochemistry > 2007 > 46 > 1 > 253 - 262

article

Oligomethylene spacer length dependent interaction of synthetic galactolipids incorporated in phospholipid layers with ricin

Hitoshi Tamiaki, Yasuo Azefu, Reiko Shibata, Reiko Sato, more

Colloids and Surfaces B: Biointerfaces > 2006 > 53 > 1 > 87-93

As models of naturally occurring glycolipids, structurally well-determined amphiphilic compounds were prepared. The synthetic molecules have β-d-galactopyranosyl or α-d-mannopyranosyl and two dodecyl groups as terminal hydrophilic sugar and hydrophobic hydrocarbon moieties, respectively. The two long alkyl chains are connected by 3,5-dioxybenzamide through ether linkages to give a lipid analog purified...

article

The structure of artificial lipids possessing oligo(ethylene glycol) and their behavior in water

Taichi Yoshitomi, Sawataka Yabuki, Hiroko Kawakami, Reiko Sato, more

Colloids and Surfaces A: Physicochemical and Engineering Aspects > 2006 > 284-285 > Complete > 276-283

The synthesis of artificial lipids containing 3,5-bis- or 3,4,5-tris(dodecyloxy)benzamide and oligo(ethylene glycol) (OEG) moieties is described. The terminal group was either an alcohol or an amine, and the length of ethylene glycol unit was three, six, eight or nine. The critical micelle concentration (CMC) of these artificial lipids was determined by a fluorescent probe method using Nile red. The...

article

Intracellular Delivery of Proteins in Complexes with Oligoarginine-Modified Liposomes and the Effect of Oligoarginine Length

Masahiko Furuhata, Hiroko Kawakami, Kazunori Toma, Yoshiyuki Hattori, more

Bioconjugate Chemistry > 2006 > 17 > 4 > 935 - 942

article

Design, synthesis and gene delivery efficiency of novel oligo-arginine-linked PEG-lipids: Effect of oligo-arginine length

Masahiko Furuhata, Hiroko Kawakami, Kazunori Toma, Yoshiyuki Hattori, more

International Journal of Pharmaceutics > 2006 > 316 > 1-2 > 109-116

The design, synthesis, and evaluation of in vitro gene delivery efficacy of a novel series of oligo-Arg-lipid conjugates are described. 3,5-Bis(dodecyloxy)benzamide (BDB) was employed as the lipid component, and a poly(ethylene glycol) (PEG) spacer was introduced between the C-terminal of oligo-Arg and the amide group of BDB. Four derivatives with various oligo-Arg lengths (ArgN-PEG-BDB; N=4, 6, 8,...

article

Effect of eel calcitonin glycosylation on incorporation and channel formation in planar phospholipid membranes

Daniela Meleleo, Silvia Micelli, Kazunori Toma, Katsuji Haneda, more

Peptides > 2006 > 27 > 4 > 805-811

Previous studies have shown that different calcitonins interact with planar lipid membranes to form ion channels. In this study, glycosylation of eel calcitonin (eCt) at different positions (Ct3-GlcNAc, Ct14-GlcNAc, Ct20-GlcNAc, Ct26-GlcNAc) is shown to preserve molecular structure and slightly change the energy of incorporation and channel formation in planar lipid bilayers made up of palmitoyl-oleoyl-phosphatidylcholine:dioleoyl...

article

Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures

Katsuji Haneda, Midori Takeuchi, Mizuka Tagashira, Toshiyuki Inazu, more

Carbohydrate Research > 2006 > 341 > 2 > 181-190

Naturally occurring glycopeptides and glycoproteins usually contain more than one glycosylation site, and the structure of the carbohydrate attached is often different from site to site. Therefore, synthetic methods for preparing peptides and proteins that are glycosylated at multiple sites, possibly with different carbohydrate structures, are needed. Here, we report a chemo-enzymatic approach for...

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Keywords

CALCITONIN (4)
OLIGOARGININE (4)
LIPOSOME (3)
MACROPINOCYTOSIS (3)
N-GLYCOSYLATION (3)
CELL CULTURE (2)
CELL-PENETRATING PEPTIDE (2)
CHEMO-ENZYMATIC SYNTHESIS (2)
GENE DELIVERY (2)
GLYCOLIPID (2)
GLYCOPEPTIDE (2)
GLYCOSYLATION (2)
PLASMONS (2)
ULTRAFAST OPTICS (2)
AGGLUTINATION (1)
ANTITUMOR EFFECT (1)
ARTIFICIAL LIPIDS (1)
BIOLOGICAL ACTIVITY (1)
CAMPTOTHECIN (1)
CELL PENETRATING PEPTIDES (1)
COATING (1)
COLON 26 TUMOR (1)
COPOLYMERS (1)
CORD BLOOD PROGENITOR CELLS (1)
CORRELATIVE LIGHT‐ELECTRON MICROSCOPY (1)
CRITICAL MICELLE CONCENTRATION (1)
DECAARGININE‐PEG‐LIPID (1)
DNA DELIVERY (1)
ECM (EXTRACELLULAR MATRIX) (1)
EEL CALCITONIN (1)
ELECTRON MICROSCOPY (1)
ENDO-M (1)
ENDO-Β-N-ACETYLGLUCOSAMINIDASE (1)
EUROPIUM COMPLEX (1)
FIBROBLAST CELLS (1)
GELS (1)
GLUCONEOGENESIS (1)
GOLD (1)
GRATINGS (1)
HELA (1)
HEPARIN (1)
HEPATOCYTES (1)
HINGE GLYCOPEPTIDES (1)
HSA (1)
HUMAN SERUM IGA1 (1)
HYDROGEL (1)
HYPOCALCEMIC ACTIVITY (1)
IGA NEPHROPATHY (1)
IGA1 (1)
IGA1-SEPHAROSE (1)
IMMUNOGLOBULIN A1 (1)
IMMUNOGLOBULINS (1)
IN VIVO TRANSFECTION (1)
INTERFERON-Β (1)
INTRATUMOR INJECTION (1)
ION CHANNEL (1)
KB (1)
LAMININ (1)
LANGMUIR-BLODGETT MEMBRANE (1)
LANTHANIDE EMISSION (1)
LASER BEAMS (1)
LASER EXCITATION (1)
LECTIN (1)
LIGAND (1)
MALDI-TOFMS (1)
MEASUREMENT BY LASER BEAM (1)
MICELLES (1)
MULTIPLE GLYCOSYLATION SITES (1)
N-LINKED OLIGOSACCHARIDE (1)
NANOSTRUCTURES (1)
NEURAMINIDASE (1)
NMR ANALYSIS (1)
NONLINEAR OPTICS (1)
NONVIRAL GENE DELIVERY (1)
NONVIRAL GENE DELIVERY VECTOR (1)
NONWOVEN FABRIC (1)
O-LINKED OLIGOSACCHARIDE (1)
OLIGO-ARGININE (1)
OLIGOSACCHARIDES (1)
OPTICAL PULSE SHAPING (1)
OPTICAL SURFACE WAVES (1)
PARTICLE SIZE DISTRIBUTION (1)
PC-3 (1)
PEPTIDE (1)
PEPTIDE-LIPID (1)
PH-DEPENDENT LUMINESCENCE (1)
PHOTOSENSITIZATION (1)
PLANAR LIPID MEMBRANE (1)
POLYSACCHARIDE (1)
POROUS CARRIER (1)
PROTAMINE (1)
RECEPTOR BINDING ACTIVITY (1)
RECOGNITION (1)
SITE-SPECIFIC FUCOSYLATION (1)
SPATIOTEMPORAL PHENOMENA (1)
STIMULI‐SENSITIVE POLYMERS (1)
STROMAL CELLS (1)
STRUCTURAL CHANGES (1)
SULFATED SUGAR (1)
THREE-DIMENSIONAL CULTURE (1)
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Elsevier (17)
Springer (6)
ACS (4)
ieee (3)
Wiley (2)

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Glycoconjugate Journal (4)
International Journal of Pharmaceutics (3)
Biochemistry (2)
Journal of Chromatography B: Biomedical Sciences and Applications (2)
Journal of Controlled Release (2)
Biochemical and Biophysical Research Communications (1)
Bioconjugate Chemistry (1)
Biomaterials (1)
Bioorganic & Medicinal Chemistry (1)
Carbohydrate Research (1)
Colloids and Surfaces A: Physicochemical and Engineering Aspects (1)
Colloids and Surfaces B: Biointerfaces (1)
Cytotechnology (1)
Journal of Applied Polymer Science (1)
Journal of Artificial Organs (1)
Journal of Bioscience and Bioengineering (1)
Journal of Photochemistry & Photobiology, A: Chemistry (1)
Peptides (1)
Tetrahedron (1)
The Journal of Gene Medicine (1)
The Journal of Physical Chemistry C (1)
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INFONA - science communication portal

Search results for: Kazunori Toma

Composition‐dependent sol‐gel transition of amphiphilic blend of PEG with hydrophobic gallamide components

Numerical demonstration of deterministic spatiotemporal control of localized plasmon pulses at metallic nanostructures by light wave shaping

Control of grating-coupled ultrafast surface plasmon pulse and its nonlinear emission by shaping femtosecond laser pulse

Spatiotemporal control of femtosecond plasmon with spectral interferometry NSOM

Laminin active peptide/agarose matrices as multifunctional biomaterials for tissue engineering

Early entry and deformation of macropinosomes correlates with high efficiency of decaarginine‐polyethylene glycol‐lipid‐mediated gene delivery

Cell line-dependent internalization pathways determine DNA transfection efficiency of decaarginine-PEG-lipid

Supramolecular gelation of alcohol and water by synthetic amphiphilic gallic acid derivatives

Decaarginine-PEG-liposome enhanced transfection efficiency and function of arginine length and PEG

Smart pH sensitive luminescent hydrogel based on Eu(III) β-diketonate complex and its enhanced photostability

High gene delivery in tumor by intratumoral injection of tetraarginine-PEG lipid-coated protamine/DNA

In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin

One-Dimensional Array of Au Nanoparticles Fixed on Nanofibers of Organogelators by the Langmuir−Blodgett Method

Isolation and Characterization of Phage-Displayed Single Chain Antibodies Recognizing Nonreducing Terminal Mannose Residues. 1. A New Strategy for Generation of Anti-Carbohydrate Antibodies ^†

Oligomethylene spacer length dependent interaction of synthetic galactolipids incorporated in phospholipid layers with ricin

The structure of artificial lipids possessing oligo(ethylene glycol) and their behavior in water

Intracellular Delivery of Proteins in Complexes with Oligoarginine-Modified Liposomes and the Effect of Oligoarginine Length

Design, synthesis and gene delivery efficiency of novel oligo-arginine-linked PEG-lipids: Effect of oligo-arginine length

Effect of eel calcitonin glycosylation on incorporation and channel formation in planar phospholipid membranes

Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures

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