Search results for: Gábor Mező

Two cyclic peptides with a thioether bond have been synthesised corresponding to the 9-22 ( ⁹ LKMADPNRFRGKDL ² ² ) sequence of glycoprotein D (gD-1) of Herpes simplex virus. The role of the secondary structure in protein-specific monoclonal antibody recognition was investigated. The sequence selected for this study comprises a strongly antigenic site adopting a β-turn at residues...

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Degranulation and superoxide production depend on cholesterol in PLB-985 cells

Krisztina Káldi, Ágnes Kalocsai, Balázs K. Rada, Gábor Mező, more

Biochemical and Biophysical Research Communications > 2003 > 310 > 4 > 1241-1246

The effect of agents disrupting cholesterol-rich microdomains of the cell membrane was studied on the chemoattractant receptor (FPR and FRPL1) coupled effector responses of promyelocytic PLB-985 cells. Both methyl-β-cyclodextrin (MβCD) and filipin III inhibited exocytosis of primary granules and O ₂ ^- -production induced by stimulation of either chemotactic receptor. Alteration of...

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Cyclohexyloxycarbonyl Based Orthogonal Solid Phase Peptide Synthesis in Boc Chemistry

Gábor Mező, Nikolett Mihala, György Kóczán, Ferenc Hudecz

Tetrahedron > 1998 > 54 > 24 > 6757-6766

Application of N-cyclohexyloxycarbonyl (Choc) protection in Boc chemistry on solid phase provides a new possibility for the preparation of protected peptide fragments. A Choc/OcHex protection scheme allows also the assembly of cyclic lactam peptides linked to the resin through the C-terminus. Choc protection is stable under the 1M TMSOTf-thioanisole/TFA cleavage condition at 0°C, but it is removable...

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Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmenbrane glycoprotein gq41 of HIV-1

Zolta´n Proha´szka, Katalin Ne´met, Pe´ter Csermely, Ferenc Hudecz, more

Molecular Immunology > 1997 > 34 > 11 > 809-816

The transmembrane gloycoprotein gp41 of HIV-1 contains a C1q binding domain (HIVenv 583–610) and activates the human complement system through the classical pathway. Based on structural and functional similarities between human defensins (human neutrophil peptide, HNP 1–3) and synthetic peptides representing the env 583–610 region of HIV-1, we found it interesting to investigate the C1q binding and...

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