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High-frequency oscillatory ventilation (HFOV) allows effective recruitment of atelectasis while delivering minimal tidal volumes at rates exceeding the normal respiratory rate. HFOV is considered in the setting of failing conventional ventilation in patients with acute lung injury, indicated by arterial hypoxaemia despite peak inspiratory pressures of more than 35cm H 2 O or oxygenation indices...
This paper describes the methodology of a clinical trial of prone positioning in pediatric patients with acute lung injury (ALI). Nonrandomized studies suggest that prone positioning improves oxygenation in patients with ALI/acute respiratory distress syndrome without the risk of serious iatrogenic injury. It is not known if these improvements in oxygenation result in improvements in clinical outcomes...
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