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Short-chain fatty acids (SCFAs), the most abundant microbial metabolites in the intestine, activate cells via G-protein−coupled receptors (GPRs), such as GPR41 and GPR43. We studied regulation of the immune response by SCFAs and their receptors in the intestines of mice.Inflammatory responses were induced in GPR41−/−, GPR43−/−, and C57BL6 (control) mice by administration of ethanol; 2, 4, 6-trinitrobenzene...
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