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Purpose
HSV‐1 keratitis (HSK) is a leading cause of infectious blindness in developed countries. Massive use of nucleosidic DNA polymerase inhibitors, used as curative or prophylactic treatments, may favor the emergence of resistance. Anti‐HSV1 small interfering RNAs (siRNA) may be efficient to overcome this issue, but their transfection into corneal cells remains a challenge. The purpose of this...
Purpose Recombinant Adeno‐Associated virus (rAVV) encoding meganucleases specifically designed to address Herpes simplex virus type 1 (HSV1) reduce HSV1 replication both in vitro and ex‐vivo. The main issue of this potential antiviral treatment is the delivery system. To evaluate a vector‐free method, we tested an electroporation process to transfer HSV1‐specific meganucleases (HSV1‐SM) to the murine...
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