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Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this treatment approach,...
Ectopic pregnancy (EP) is the leading cause of maternity‐related death in the first trimester of pregnancy. Approximately 98% of ectopic implantations occur in the fallopian tube, and expedient management is crucial for preventing hemorrhage and maternal death in the event of tubal rupture. Current ultrasound strategies misdiagnose EP in up to 40% of cases, and the failure rate of methotrexate treatment...
This study presents the first messenger RNA (mRNA) therapy for metastatic ovarian cancer and cachexia‐induced muscle wasting based on lipid nanoparticles that deliver follistatin (FST) mRNA predominantly to cancer clusters following intraperitoneal administration. The secreted FST protein, endogenously synthesized from delivered mRNA, efficiently reduces elevated activin A levels associated with aggressive...
Ovarian Cancer Treatment
In article number 2204436 by Daniel L. Marks, Oleh Taratula, and co‐workers, follistatin mRNA delivered by lipid nanoparticles targets ovarian cancer clusters dispersed in the peritoneal cavity of mice. When combined with platinum chemotherapy, the proposed treatment may allow complete cytoreduction, enhance resilience to the iatrogenic burden of chemotherapeutic intervention,...
Endometriosis Treatment
In article number 2107808, Ov D. Slayden, Oleh Taratula, and co‐worker develop an endometriosis therapy based on targeted magnetic nanoparticles that efficiently accumulate in endometriotic lesions following systemic administration, and specifically eradicate the disease by generating therapeutic temperatures inside the lesions upon exposure to an external alternating magnetic...
Endometriosis is a devastating disease in which endometrial‐like tissue forms lesions outside the uterus. It causes infertility and severe pelvic pain in ≈176 million women worldwide, and there is currently no cure for this disease. Magnetic hyperthermia could potentially eliminate widespread endometriotic lesions but has not previously been considered for treatment because conventional magnetic nanoparticles...
Endometriosis is an incurable gynecological disease characterized by the abnormal growth of endometrium‐like tissue, characteristic of the uterine lining, outside of the uterine cavity. Millions of people with endometriosis suffer from pelvic pain and infertility. This review aims to discuss whether nanomedicines that are promising therapeutic approaches for various diseases have the potential to...
In article number 1906936, Ov D. Slayden, Oleh Taratula, and co‐workers present a nanomedicine approach for endometriosis treatment. Photo‐responsive nanoparticles concurrently delineate and ablate endometriosis tissue xenografts in mice employing real‐time fluorescence imaging and photothermal therapy. Following intravenous injection, nanoparticles activate their fluorescence in endometriotic lesions...
Endometriosis is a painful disorder where endometrium‐like tissue forms lesions outside of the uterine cavity. Intraoperative identification and removal of these lesions are difficult. This study presents a nanoplatform that concurrently delineates and ablates endometriosis tissues using real‐time near‐infrared (NIR) fluorescence and photothermal therapy (PTT). The nanoplatform consists of a dye,...
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