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Engineered nanomaterials (ENMs) are used in food additives, food packages, and therapeutic purposes owing to their useful properties, Therefore, human beings are orally exposed to exogenous nanomaterials frequently, which means the intestine is one of the primary targets of nanomaterials. Consequently, it is of great importance to understand the interaction between nanomaterials and the intestine...
In the past decades, nanotechnology has stimulated a huge amount of interest and is now used in numerous fields. Carbon nanomaterials, like graphene, carbon nanotubes, and fullerenes, have attracted great attention for their widespread applications in diverse fields because of their excellent mechanical, optical, and thermal properties. With substantial production and use, potential human exposure...
Exocytosis of single‐walled carbon nanotubes (SWCNTs) determines therapeutic efficiency and toxicity of nanoproducts but its underlying mechanism remains elusive. In this study, it is found that the exocytosis mechanism of SWCNTs is mediated mainly through the activation of P2X7 receptor (P2X7R), an ATP‐gated membrane receptor highly expressed in macrophages. Inhibition of P2X7R signaling by either...
The exocytosis and underlying mechanism of single‐walled carbon nanotubes (SWCNTs) in macrophages is revealed by B. Wan, L.‐H. Guo, and co‐workers on page 5998. Exocytosis of SWCNTs is initiated by the activation of the P2X7 receptor, which accounts for the lysosomal secretion pathway as a potential mechanism for cells to repel SWCNTs. The cover image shows microtubules providing orbits for the exocytosis...
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