Search results for: Hiroto Katoh

Items from 1 to 20 out of 20 results

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Immune repertoire profiling for disease pathobiology

Hiroto Katoh, Daisuke Komura, Genta Furuya, Shumpei Ishikawa

Pathology International > 73 > 1 > 1 - 11

Lymphocytes consist of highly heterogeneous populations, each expressing a specific cell surface receptor corresponding to a particular antigen. Lymphocytes are both the cause and regulator of various diseases, including autoimmune/allergic diseases, lifestyle diseases, neurodegenerative diseases, and cancers. Recently, immune repertoire sequencing has attracted much attention because it helps obtain...

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Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers

Bin Liu, Hiroto Katoh, Daisuke Komura, Asami Yamamoto, more

The Journal of Pathology > 258 > 2 > 106 - 120

Efficient molecular targeting therapies for most gastric cancers (GCs) are currently lacking, despite GC being one of the most frequent and often devastating malignancies worldwide. Thus, identification of novel therapeutic targets for GC is in high demand. Recent advancements of high‐throughput nucleic acid synthesis methods combined with next‐generation sequencing (NGS) platforms have made it feasible...

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KRAS mutation in intrahepatic cholangiocarcinoma: Linkage with metastasis‐free survival and reduced E‐cadherin expression

Mariko Tanaka, Akiko Kunita, Makoto Yamagishi, Hiroto Katoh, more

Liver International > 42 > 10 > 2329 - 2340

Background and Aims Although KRAS mutations are the major driver of intrahepatic cholangiocarcinoma (ICC), their role remains unexplored. This study aimed to elucidate the prognostic effects, association with clinicopathologic characteristics and potent functions of KRAS mutations in ICC. Methods A hundred and seven resected stage I–III ICCs were analysed for KRAS mutation status and its link with...

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Clinicopathological and molecular analyses of linearly expanded epithelial cells with β‐catenin alterations, “β‐catenin signature”, in the normal fallopian tube

Kei Koyama, Daichi Maeda, Masahiko Kito, Daisuke Tamura, more

Histopathology > 77 > 6 > 880 - 889

Aims Recent advances in next‐generation sequencing have made it clear that clonal expansion of cells harbouring driver gene mutations occurs in physiologically normal epithelium. Molecular analysis of tubal epithelium has been almost exclusively confined to the TP53 pathway, which is involved in serous carcinogenesis. Other oncogenic events have not been explored in detail. Here, we report the linear...

article

Capturing the differences between humoral immunity in the normal and tumor environments from repertoire-seq of B-cell receptors using supervised machine learning

Hiroki Konishi, Daisuke Komura, Hiroto Katoh, Shinichiro Atsumi, more

BMC Bioinformatics > 2019 > 20 > 1 > 1-11

Background The recent success of immunotherapy in treating tumors has attracted increasing interest in research related to the adaptive immune system in the tumor microenvironment. Recent advances in next-generation sequencing technology enabled the sequencing of whole T-cell receptors (TCRs) and B-cell receptors (BCRs)/immunoglobulins (Igs) in the tumor microenvironment. Since BCRs/Igs in tumor tissues...

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EVI1 expression is associated with aggressive behavior in intrahepatic cholangiocarcinoma

Mariko Tanaka, Junji Shibahara, Shumpei Ishikawa, Tetsuo Ushiku, more

Virchows Archiv > 2019 > 474 > 1 > 39-46

Ecotropic virus integration site 1 protein homolog (EVI1), a well-known oncogenic transcriptional factor of hematopoietic cells, contributes to pancreatic cancer oncogenicity through increased expression of KRAS. Because EVI1 was upregulated in cholangiocarcinoma by referring The Cancer Genome Atlas, we investigated the importance of EVI1 in intrahepatic cholangiocarcinoma (ICC) which has been regarded...

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The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses

Yae Kanai, Hiroshi Nishihara, Yohei Miyagi, Tatsuhiro Tsuruyama, more

Pathology International > 68 > 2 > 63 - 90

Genome research using appropriately collected pathological tissue samples is expected to yield breakthroughs in the development of biomarkers and identification of therapeutic targets for diseases such as cancers. In this connection, the Japanese Society of Pathology (JSP) has developed “The JSP Guidelines on the Handling of Pathological Tissue Samples for Genomic Research” based on an abundance...

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Immunogenetic Profiling for Gastric Cancers Identifies Sulfated Glycosaminoglycans as Major and Functional B Cell Antigens in Human Malignancies

Hiroto Katoh, Daisuke Komura, Hiroki Konishi, Ryohei Suzuki, more

Cell Reports > 2017 > 20 > 5 > 1073-1087

Recent successes in tumor immunotherapies have highlighted the importance of tumor immunity. However, most of the work conducted to date has been on T cell immunity, while the role of B cell immunity in cancer remains more elusive. In this study, immunogenetic repertoire profiling for tumor-infiltrating B and T cells in gastric cancers was carried out to help reveal the architecture of B cell immunity...

article

Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing

Yukinobu Ito, Daichi Maeda, Makoto Yoshida, Akihiko Yoshida, more

Virchows Archiv > 2017 > 471 > 3 > 423-428

Electronic supplementary material The online version of this article (doi: 10.1007/s00428-017-2135-x ) contains supplementary material, which is available to authorized users.

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Genomic pathobiology of gastric carcinoma

Hiroto Katoh, Shumpei Ishikawa

Pathology International > 67 > 2 > 63 - 71

With the recent advances in genome sequencing technologies, comprehensive cancer genomic profiling has revealed the in‐depth molecular mechanisms of gastric malignancies. New insights into the carcinogenesis pathways of gastric cancers have been acquired, not only by DNA sequencing, but also by the expression profiling of the transcriptome, the identification of chimeric genes, and epi‐genetic profiling...

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CASTIN: a system for comprehensive analysis of cancer-stromal interactome

Daisuke Komura, Takayuki Isagawa, Kazuki Kishi, Ryohei Suzuki, more

BMC Genomics > 2016 > 17 > 1 > 1-18

Background Cancer microenvironment plays a vital role in cancer development and progression, and cancer-stromal interactions have been recognized as important targets for cancer therapy. However, identifying relevant and druggable cancer-stromal interactions is challenging due to the lack of quantitative methods to analyze whole cancer-stromal interactome. Results We present CASTIN (CAncer-STromal...

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RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases

Tetsuo Ushiku, Shumpei Ishikawa, Miwako Kakiuchi, Atsushi Tanaka, more

Gastric Cancer > 2016 > 19 > 2 > 403-411

Background Recent studies have discovered recurrent RHOA mutations in diffuse-type gastric cancers. These reports show mutant RhoA is an important cancer driver and is a potential therapeutic target. This study aims to investigate the clinicopathological features of diffuse-type gastric cancers with RHOA mutation. Methods We performed a thorough review of 87 diffuse-type gastric cancers, including...

article

FOXP3: Genetic and epigenetic implications for autoimmunity

Hiroto Katoh, Pan Zheng, Yang Liu

Journal of Autoimmunity > 2013 > 41 > Complete > 72-78

FOXP3 plays an essential role in the maintenance of self-tolerance and, thus, in preventing autoimmune diseases. Inactivating mutations of FOXP3 cause immunodysregulation, polyendocrinopathy, and enteropathy, X-linked syndrome. FOXP3-expressing regulatory T cells attenuate autoimmunity as well as immunity against cancer and infection. More recent studies demonstrated that FOXP3 is an epithelial cell-intrinsic...

article

Epithelial Homeostasis: Elimination by Live Cell Extrusion

Hiroto Katoh, Yasuyuki Fujita

Current Biology > 2012 > 22 > 11 > R453-R455

To maintain a functional and harmonious epithelial society, the number and quality of cells need to be tightly controlled. Two recent studies reveal a novel cellular process for epithelial homeostasis: crowding-mediated live cell extrusion.

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FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1

Hiroto Katoh, Zhaohui S. Qin, Runhua Liu, Lizhong Wang, more

Molecular Cell > 2011 > 44 > 5 > 770-784

Both H4K16 acetylation and H3K4 trimethylation are required for gene activation. However, it is still largely unclear how these modifications are orchestrated by transcriptional factors. Here, we analyzed the mechanism of the transcriptional activation by FOXP3, an X-linked suppressor of autoimmune diseases and cancers. FOXP3 binds near transcriptional start sites of its target genes. By recruiting...

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Signalling through FOXP3 as an X-linked tumor suppressor

Hiroto Katoh, Pan Zheng, Yang Liu

International Journal of Biochemistry and Cell Biology > 2010 > 42 > 11 > 1784-1787

The FOXP3 (forkhead box P3) gene is a member of forkhead winged helix family transcription factors and functions as both a transcriptional activator and a repressor. FOXP3 dysfunction is responsible for an X-linked autoimmune syndrome: immune dysregulation, polyendopathy, enterophathy, X-linked syndrome. In addition to its role as an essential transcription factor in regulatory T cells, the FOXP3...

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Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate

Lizhong Wang, Runhua Liu, Weiquan Li, Chong Chen, more

Cancer Cell > 2009 > 16 > 4 > 336-346

Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer. Lineage-specific ablation of FoxP3 in the mouse prostate epithelial cells leads to prostate hyperplasia and prostate intraepithelial...

article

Genetically Distinct and Clinically Relevant Classification of Hepatocellular Carcinoma: Putative Therapeutic Targets

Hiroto Katoh, Hidenori Ojima, Akiko Kokubu, Shigeru Saito, more

Gastroenterology > 2007 > 133 > 5 > 1475-1486

Background & Aims: The biological aggressiveness of hepatocellular carcinoma (HCC) and the lack of optimal therapeutic strategies have rendered the disease a major challenge. Highly heterogeneous genetic alteration profiles of HCC have made it difficult to identify effective tailor-made molecular therapeutic targets. Therefore, classification of HCC into genetically homogeneous subclasses would...

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Epigenetic Instability and Chromosomal Instability in Hepatocellular Carcinoma

Hiroto Katoh, Tatsuhiro Shibata, Akiko Kokubu, Hidenori Ojima, more

The American Journal of Pathology > 2006 > 168 > 4 > 1375-1384

The aim of this study was to clarify the association between the epigenetic instability phenotype and the chromosomal instability phenotype in primary hepatocellular carcinoma (HCC). Sixty primary HCC tumors were examined. Methylation status for nine CpG islands (the p16, COX2, GSTP1, RASSF1A, E-cadherin, and APC gene promoters, and the MINT 1, 25, and 31 clones) was evaluated by methylation-specific...

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Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: Identification of genetic indicators to predict patient outcome

Hiroto Katoh, Tatsuhiro Shibata, Akiko Kokubu, Hidenori Ojima, more

Journal of Hepatology > 2005 > 43 > 5 > 863-874

We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma.We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones.Frequent (>30%) chromosomal losses on 1p36.1, 4q21-25, 4q34-35.1, 8p23.3b-11.1, 13q14.1-14.3, 16p13.3, 16q22.1-24.3b,...

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