Search results for: Hao Lin

Items from 1 to 20 out of 983 results

article

BRAF V600E mutation mediates invasive and growth features in ameloblastoma

Chen‐Xi Zhang, Lin‐Zhou Zhang, Hao Lin, Qi‐Wen Man, more

Objectives Ameloblastoma (AM), a locally aggressive tumor with extensive growth capacity, causes significant damage to the jaw and affects facial appearance. Although the high prevalence of BRAF V600E mutation in AM is known, its specific impacts on patients with AM remain unclear. Thus, the present study investigated the role of BRAF V600E mutation, thereby focusing on its impact on AM invasion...

article

Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology

Pei‐Hao Lin, Hai‐Yan Yao, Li Huang, Cong‐Cong Fu, more

CNS Neuroscience & Therapeutics > 30 > 9 > n/a - n/a

Objective The objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin‐4 or glial fibrillary acidic protein (GFAP) antibodies, while evaluating associated biomarkers and pathologies. Methods Patient serum and cerebrospinal fluid (CSF) were tested for antibodies using tissue‐ and cell‐based assays. Neurofilament light chain (NFL) and GFAP in...

article

Identification of vilazodone as a novel plasminogen activator inhibitor to overcome Alzheimer's disease through virtual screening, molecular dynamics simulation, and biological evaluation

Wenxiu Sun, Xuan Sheng, Peiru Li, Runwu Li, more

Archiv der Pharmazie > 357 > 9 > n/a - n/a

Urokinase‐type plasminogen activator (PLAU), a member of the S1 serine peptidase family in Clan PA, plays a crucial role in the conversion of plasminogen into active plasmin. However, the precise role of PLAU in the central nervous system remains incompletely elucidated, particularly, in relation to Alzheimer's disease (AD). In this study, we successfully identified that PLAU could promote cell senescence...

article

Humidity‐Responsive Liquid Metal Core–Shell Materials for Enduring Heat Retention and Insulation

Xuanhan Chen, Mingyuan Sun, Lu Cao, Huarui Rong, more

Advanced Materials > 36 > 33 > n/a - n/a

High humidity in extremely cold weather can undermine the insulation capability of the clothing, imposing serious life risks. Current clothing insulation technologies have inherent deficiencies in terms of insulation efficiency and humidity adaptability. Here, humidity‐stimulated self‐heating clothing using aluminum core–liquid metal shell microparticles (Al@LM‐MPs) as the filler is reported. Al@LM‐MPs...

article

Shape recovery and energy absorption properties of 3D printed continuous ramie fiber reinforced thin‐walled biocomposite structures

Hao Lin, Ruijun Cai, Ping Cheng, Jin Wang, more

Polymer Composites > 45 > 12 > 10976 - 10988

Continuous fiber reinforced composites are widely used in thin‐walled structures due to their high specific strength and stiffness. In this work, continuous natural fiber was introduced into thin‐walled biocomposite structures via 3D printing technique to enhance energy absorbing properties and promote ecological compatibility. The effects of varying configurations of printing speed, layer thickness,...

article

Theoretical limiting‐efficiency assessment on advanced crystalline silicon solar cells with Auger ideality factor and wafer thickness modifications

Qiao Su, Hao Lin, Genshun Wang, Hanbo Tang, more

Progress in Photovoltaics: Research and Applications > 32 > 9 > 587 - 598

With the improvement of surface passivation, bulk recombination is becoming an indispensable and decisive factor to assess the theoretical limiting efficiency (

η_{\lim}

) of crystalline silicon (c‐Si) solar cells. In simultaneous consideration of surface and bulk recombination, a modified model of

η_{\lim}

evaluation is developed. Surface recombination is directly depicted with contact selectivity while...

article

Diagnosis and management of inflammatory bowel disease

Lili Li, Rui Cheng, Yushan Wu, Hao Lin, more

Journal of Evidence‐Based Medicine > 17 > 2 > 409 - 433

Inflammatory bowel disease (IBD) is a chronic and relapsing immune‐mediated disease of the gastrointestinal tract with a gradually increasing global incidence and prevalence. A prolonged course of IBD leads to a decline in patient quality of life and the creation of a substantial economic burden on society. Owing to the lack of specific diagnostic markers, the diagnosis of IBD still needs a gold standard...

article

Sequence‐based design and construction of synthetic nanobody library

Chuanyong Liu, Yanping Li, Qinghua He, Jinheng Fu, more

Biotechnology and Bioengineering > 121 > 6 > 1973 - 1985

Nanobody (Nb), the smallest antibody fragments known to bind antigens, is now widely applied to various studies, including protein structure analysis, bioassay, diagnosis, and biomedicine. The traditional approach to generating specific nanobodies involves animal immunization which is time‐consuming and expensive. As the understanding of the antibody repertoire accumulation, the synthetic library,...

article

Development and validation of a rule‐based algorithm to identify periodontal diagnosis using structured electronic health record data

Bunmi Tokede, Ryan Brandon, Chun‐Teh Lee, Guo‐Hao Lin, more

Journal of Clinical Periodontology > 51 > 5 > 547 - 557

Aim To develop and validate an automated electronic health record (EHR)‐based algorithm to suggest a periodontal diagnosis based on the 2017 World Workshop on the Classification of Periodontal Diseases and Conditions. Materials and Methods Using material published from the 2017 World Workshop, a tool was iteratively developed to suggest a periodontal diagnosis based on clinical data within the...

article

Melatonin alleviates ischemic stroke by inhibiting ferroptosis through the CYP1B1/ACSL4 pathway

Yu Sun, Haiyan Jin, Jia He, Jinyu Lai, more

Environmental Toxicology > 39 > 5 > 2623 - 2633

This study utilized middle cerebral artery occlusion (MCAO) mouse models and HT‐22 cell oxygen and glucose deprivation/reoxygenation (OGD/R) models to investigate the therapeutic effects of melatonin on ischemic brain injury. In the experiments, MCAO mice were treated with 5 and 10 mg/kg doses of melatonin, and H‐T22 cells underwent OGD/R treatment and were administered different concentrations of...

article

Urbanisation drives inter‐ and intraspecific variation in flight‐related morphological traits of aquatic insects at different landscape scales

Wenfei Liao, Hao Lin

Insect Conservation and Diversity > 17 > 2 > 287 - 303

Urbanisation, as an unstoppable global phenomenon, has led to decreasing connectivity between habitats, which gives strong pressure on organisms. Current research has barely investigated urban effects on aquatic insect species traits. Here, we investigated how inter‐ and intraspecific variations of flight‐related morphological traits change along an urban gradient in three species of Dytiscidae at...

article

Consistency in human papillomavirus type detection between self‐collected vaginal specimens and physician‐sampled cervical specimens

Hung‐Hsueh Chou, Chung‐Yao Yang, Angel Chao, Hao Lin, more

Journal of Medical Virology > 96 > 3 > n/a - n/a

With the rising need for accessible cervical cancer screening, self‐sampling methods offer a promising alternative to traditional physician‐led sampling. This study aims to evaluate the efficacy of the HygeiaTouch Self Sampling Kit for Women in detecting human papillomavirus (HPV) types and predicting cervical lesions. We studied the concordance in identifying high‐risk HPV (hrHPV) types between samples...

article

Selective 1,2‐Hydroarylation(Alkenylation) of gem‐Difluoroalkenes to Access (−CF₂H) Motifs

Leroy Qi Hao Lin, Ángel Rentería‐Gómez, Robert T. Martin, Ying‐Qi Zhang, more

Angewandte Chemie International Edition > 63 > 7 > n/a - n/a

An emerging class of C−C coupling transformations that furnish drug‐like building blocks involves catalytic hydrocarbonation of alkenes. However, despite notable advances in the field, hydrocarbon addition to gem‐difluoroalkenes without additional electronic activation remains largely unsuccessful. This owes partly to poor reactivity and the propensity of difluoroalkenes to undergo defluorinative...

article

Selective 1,2‐Hydroarylation(Alkenylation) of gem‐Difluoroalkenes to Access (−CF₂H) Motifs

Leroy Qi Hao Lin, Ángel Rentería‐Gómez, Robert T. Martin, Ying‐Qi Zhang, more

Angewandte Chemie > 136 > 7 > n/a - n/a

article

Action‐time‐controlled tabletop gamification improves physician‒nurse collaborative emergency room evacuation training

Po‐Hua Wang, Hung‐Chieh Chang, Ming‐Yuan Hong, I‐Chen Lin, more

Journal of Contingencies and Crisis Management > 32 > 1 > n/a - n/a

This article is an example of Lessons from the Field highlighting the practical implementation of a novel time‐controlled mechanism in the gamification of emergency department evacuation training via tabletop exercise. Tabletop exercise is one of the most common drill types for disaster preparedness. It is easy to use, effective, and low in cost, but it has some shortcomings. For example, its lack...

article

Characterization of the proteome changes in an in vitro hyperosmotic dry eye model employing human corneal epithelial cells

Hao Lin, Caroline Manicam, Norbert Pfeiffer, Franz Grus, more

Acta Ophthalmologica > 102 > S279 > n/a - n/a

Aims/Purpose: The detrimental effects of tear hyperosmolarity on human corneal epithelial (HCE) cells is a primary cause of dry eye syndrome (DES). However, the molecular mechanisms underlying inflammatory processes and cellular dysfunction in HCE are largely unknown. This study characterized the proteome changes in an optimized hyperosmolarity‐induced DES model in vitro. Methods: An in vitro hyperosmolar...

article

In situ and General Multidentate Ligand Passivation Achieves Efficient and Ultra‐Stable CsPbX₃ Perovskite Quantum Dots for White Light‐Emitting Diodes

Yongfeng Liu, Xiuwen Shao, Zhaoju Gao, Qingyu Xie, more

Small > 20 > 3 > n/a - n/a

Inorganic CsPbX₃ perovskite quantum dots (PeQDs) show great potential in white light‐emitting diodes (WLEDs) due to excellent optoelectronic properties, but their practical application is hampered by low photoluminescence quantum yield (PLQY) and especially poor stability. Herein, we developed an in‐situ and general multidentate ligand passivation strategy that allows for CsPbX₃ PeQDs not only near‐unit...

article

Liaw's Ellipse Anteversion Method for Distinguishing Acetabular Component Retroversion from Anteversion on Plain Radiographs

Chun‐Hao Lin, Wei‐Cheng Chen, Pei‐Wei Weng, Yu‐min Huang, more

Orthopaedic Surgery > 16 > 1 > 276 - 281

Improper acetabulum component position is a significant risk factor for postoperative dislocation after total hip arthroplasty. Several radiographic two‐dimensional methods exist for measuring acetabulum component anteversion, but they cannot distinguish between anteversion and retroversion. “Liaw's version,” initially proposed as a simple mathematical standardized two‐dimensional method, was modified...

article

NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation

Xin Guo, Le Jiao, Yang Yi, Hao‐Lin Zhang, more

Journal of Cellular Physiology > 239 > 1 > n/a - n/a

Oocyte maturation defect can lead to maternal reproduction disorder. NAMPT is a rate‐limiting enzyme in mammalian NAD⁺ biosynthesis pathway, which can regulate a variety of cellular metabolic processes including glucose metabolism and DNA damage repair. However, the function of NAMPT in porcine oocytes remains unknown. In this study, we showed that NAMPT involved into multiple cellular events during...

article

Anti‐cytokine antibodies attenuated neuroglial degeneration under hypoxic stress

Chaoqiang Guan, Linglin Zhang, Natarajan Perumal, Hao Lin, more

Acta Ophthalmologica > 102 > S279 > n/a - n/a

Aims/Purpose: Hypoxia is a vital cause of neurodegenerative diseases such as glaucoma and retinal ischemia. We investigated the potential neuroprotective effects of anti‐cytokine antibodies against hypoxic damage. Methods: An in vitro hypoxia model was established using cobalt chloride (CoCl₂) stimulation in microglial cells (BV‐2). Immunofluorescence staining was performed to detect the expression...

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INFONA - science communication portal

Search results for: Hao Lin

BRAF V600E mutation mediates invasive and growth features in ameloblastoma

Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology

Identification of vilazodone as a novel plasminogen activator inhibitor to overcome Alzheimer's disease through virtual screening, molecular dynamics simulation, and biological evaluation

Humidity‐Responsive Liquid Metal Core–Shell Materials for Enduring Heat Retention and Insulation

Shape recovery and energy absorption properties of 3D printed continuous ramie fiber reinforced thin‐walled biocomposite structures

Theoretical limiting‐efficiency assessment on advanced crystalline silicon solar cells with Auger ideality factor and wafer thickness modifications

Diagnosis and management of inflammatory bowel disease

Sequence‐based design and construction of synthetic nanobody library

Development and validation of a rule‐based algorithm to identify periodontal diagnosis using structured electronic health record data

Melatonin alleviates ischemic stroke by inhibiting ferroptosis through the CYP1B1/ACSL4 pathway

Urbanisation drives inter‐ and intraspecific variation in flight‐related morphological traits of aquatic insects at different landscape scales

Consistency in human papillomavirus type detection between self‐collected vaginal specimens and physician‐sampled cervical specimens

Selective 1,2‐Hydroarylation(Alkenylation) of gem‐Difluoroalkenes to Access (−CF₂H) Motifs

Selective 1,2‐Hydroarylation(Alkenylation) of gem‐Difluoroalkenes to Access (−CF₂H) Motifs

Action‐time‐controlled tabletop gamification improves physician‒nurse collaborative emergency room evacuation training

Characterization of the proteome changes in an in vitro hyperosmotic dry eye model employing human corneal epithelial cells

In situ and General Multidentate Ligand Passivation Achieves Efficient and Ultra‐Stable CsPbX₃ Perovskite Quantum Dots for White Light‐Emitting Diodes

Liaw's Ellipse Anteversion Method for Distinguishing Acetabular Component Retroversion from Anteversion on Plain Radiographs

NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation

Anti‐cytokine antibodies attenuated neuroglial degeneration under hypoxic stress

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