The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Kleine-Levin syndrome (KLS) is a rare disease with symptoms that include episodic hypersomnia, cognitive and behavioral disturbances. Its pathogenesis is now unknown. Hypocretin levels were studied in KLS patients to determine the role of hypocretin in KLS.CSF samples were collected at 10:00–13:00 from 42 patients diagnosed with KLS in Peking university People’s hospital from 2002 to 2012. 53 control...
Background: To test if the hypocretin (orexin) neuropeptide precursor (HCRT) gene, HCRT, mutations are implicated in the development of narcolepsy with cataplexy deficiency in young children. Methods: The entire HCRT gene and ~2000bp promoter region was first sequenced in 181 patients and 153 controls, and rare polymorphisms including three nonsynonymous amino acid changes were identified. Next the...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.