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Since 2016, 3 innovative therapies for spinal muscular atrophy (SMA) have changed the face of the disease. Although these therapies often result in remarkable improvements in infants and children, benefits in adults are modest and treatment is not curative. Concerns have been raised about the enormous costs of these medications, the ultimate burden to taxpayers, and the costs to society of withholding...
The T‐box transcription factor, T‐bet promotes the differentiation of short‐lived effector CD8+ T cells at the expense of central memory cells. How T‐bet mediates these effects, and whether they are directly caused by T‐bet alone are unknown, because expression of T‐bet requires stimulation of the T cell by inflammatory and growth cytokines, which may have T‐bet‐independent functions involving T‐cell...
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