Search results for: Bhavana S. Solanky

Items from 1 to 6 out of 6 results

article

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Bhavana S. Solanky, Ferran Prados, Carmen Tur, Marios C. Yiannakas, more

Journal of Magnetic Resonance Imaging > 52 > 5 > 1429 - 1438

Background Associations between brain total sodium concentration, disability, and disease progression have recently been reported in multiple sclerosis. However, such measures in spinal cord have not been reported. Purpose To measure total sodium concentration (TSC) alterations in the cervical spinal cord of people with relapsing–remitting multiple sclerosis (RRMS) and a control cohort using sodium...

article

Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

Ian Marshall, Michael J. Thrippleton, Mark E. Bastin, Daisy Mollison, more

Journal of Neurology > 2018 > 265 > 8 > 1795-1802

Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white...

article

Bi‐exponential ²³Na T₂* component analysis in the human brain

Frank Riemer, Bhavana S. Solanky, Claudia A.M. Wheeler‐Kingshott, Xavier Golay

NMR in Biomedicine > 31 > 5 > n/a - n/a

The purpose of this study was to measure the sodium transverse relaxation time T₂* in the healthy human brain. Five healthy subjects were scanned with 18 echo times (TEs) as short as 0.17 ms. T₂* values were fitted on a voxel‐by‐voxel basis using a bi‐exponential model. Data were also analysed using a continuous distribution fit with a region of interest‐based inverse Laplace transform. Average T₂...

article

Sodium (²³Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory

Frank Riemer, Bhavana S. Solanky, Christian Stehning, Matthew Clemence, more

Magnetic Resonance Materials in Physics, Biology and Medicine > 2014 > 27 > 1 > 35-46

Object Sodium magnetic resonance imaging (²³Na-MRI) of the brain has shown changes in ²³Na signal as a hallmark of various neurological diseases such as stroke, Alzheimer’s disease, Multiple Sclerosis and Huntington’s disease. To improve scan times and image quality, we have implemented the 3D-Cones (CN) sequence for in vivo ²³Na brain MRI. Materials and methods Using signal-to-noise (SNR) as a...

article

Sodium quantification in the spinal cord at 3T

Bhavana S. Solanky, Frank Riemer, Xavier Golay, Claudia A. M. Wheeler‐Kingshott

Magnetic Resonance in Medicine > 69 > 5 > 1201 - 1208

Purpose:Sodium channels are involved in neuronal function and therefore methods to assess tissue sodium concentration in vivo are exceptionally appealing. Recently there has been a renewed interest for brain sodium magnetic resonance imaging (MRI), thanks to higher magnetic field strength scanners. However, sodium measures in the spinal cord are lacking due to major technical challenges. Here we propose...

article

In vivo magnetic resonance spectroscopy detection of combined glutamate‐glutamine in healthy upper cervical cord at 3 T

Bhavana S Solanky, Khaled Abdel‐Aziz, Marios C Yiannakas, Alaine M Berry, more

NMR in Biomedicine > 26 > 3 > 357 - 366

The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹ H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of interest due to its small volume, magnetic field inhomogeneities and physiological motion...

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Search results for: Bhavana S. Solanky

Sodium in the Relapsing–Remitting Multiple Sclerosis Spinal Cord: Increased Concentrations and Associations With Microstructural Tissue Anisotropy

Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

Bi‐exponential 23Na T2* component analysis in the human brain

Sodium (23Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory

Sodium quantification in the spinal cord at 3T

In vivo magnetic resonance spectroscopy detection of combined glutamate‐glutamine in healthy upper cervical cord at 3 T

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Bi‐exponential ²³Na T₂* component analysis in the human brain

Sodium (²³Na) ultra-short echo time imaging in the human brain using a 3D-Cones trajectory