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The RNA polymerase‐binding protein DksA, together with the alarmone nucleotides (p)ppGpp, mediates the stringent response to nutrient starvation in Borrelia burgdorferi. To date, the contribution of DksA to B. burgdorferi infection remains unknown. We report here that DksA is essential for B. burgdorferi to infect a mammalian host. dksA expression was highly induced during infection. Moreover, a dksA...
Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon‐2. To date, the contribution of Lon‐2 to B. burgdorferi fitness and infection remains unexplored. Herein, we showed that expression of lon‐2 was highly induced during animal infection, suggesting that Lon‐2 is important for B. burgdorferi infection. We further generated a lon‐2 deletion mutant. Compared with that...
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