Search results for: Hugh Kearney

Items from 1 to 10 out of 10 results

article

Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable

David Lewis‐Smith, Peter D. Galer, Ganna Balagura, Hugh Kearney, more

Epilepsia > 62 > 6 > 1293 - 1305

Objective The clinical features of epilepsy determine how it is defined, which in turn guides management. Therefore, consideration of the fundamental clinical entities that comprise an epilepsy is essential in the study of causes, trajectories, and treatment responses. The Human Phenotype Ontology (HPO) is used widely in clinical and research genetics for concise communication and modeling of clinical...

article

Differences in neurology residency training programmes across Europe – a survey among the Residents and Research Fellow Section of the European Academy of Neurology national representatives

N. N. Kleineberg, M. Meulen, C. Franke, L. Klingelhoefer, more

European Journal of Neurology > 27 > 8 > 1356 - 1363

Background and purpose Neurology is rapidly evolving as a result of continuous diagnostic and therapeutic progress, which influences the daily work of neurologists. Therefore, updating residency training programmes is crucial for the future of neurology. Several countries are currently discussing and/or modifying the structure of their neurology residency training programme. A detailed and up‐to‐date...

article

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course—a biopsy study

Hugh Kearney, Tucker Price, Jane Cryan, Alan Beausang, more

Irish Journal of Medical Science ( 01971 -) > 2019 > 188 > 4 > 1427-1434

Background Knowledge of the clinical outcome in tumefactive demyelination remains limited. Aims This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population. Methods We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. A baseline, and at least one follow-up...

article

Evaluation of the specificity of the central diagnostic criterion for chronic traumatic encephalopathy

Jennifer Lorigan, Hugh Kearney, Bryan Grimes, Josephine Heffernan, more

Irish Journal of Medical Science ( 01971 -) > 2019 > 188 > 3 > 993-998

Introduction Chronic traumatic encephalopathy (CTE) is a postmortem diagnosis. Consensus postmortem, but not antemortem, diagnostic criteria have been established. A key factor in these criteria is evidence of phosphorylated-tau (p-tau) around sulcal vessels in the cortex. However, this sign has been observed anecdotally in a diverse range of neurodegenerative diseases (NDD). We therefore hypothesise...

article

Machine learning: a useful radiological adjunct in determination of a newly diagnosed glioma’s grade and IDH status

Céline Looze, Alan Beausang, Jane Cryan, Teresa Loftus, more

Journal of Neuro-Oncology > 2018 > 139 > 2 > 491-499

Introduction Machine learning methods have been introduced as a computer aided diagnostic tool, with applications to glioma characterisation on MRI. Such an algorithmic approach may provide a useful adjunct for a rapid and accurate diagnosis of a glioma. The aim of this study is to devise a machine learning algorithm that may be used by radiologists in routine practice to aid diagnosis of both: WHO...

article

Neuropathology correlates of cognitive assessments

Francesca M. Brett, Hugh Kearney

Irish Journal of Medical Science ( 01971 -) > 2018 > 187 > 3 > 835-844

Background Alzheimer’s disease and other dementias are the fourth largest contributors to neurological disability and the second largest contributor to deaths from neurological disease. Described in the 1980s as ‘the silent epidemic’ these disorders principally, though not exclusively, affect persons 80 years or older, and in developed countries, this ‘old old’ population continues to grow. Definitive...

article

MRI and multiple sclerosis––the evolving role of MRI in the diagnosis and management of MS: the radiologist’s perspective

Alexis M. Cahalane, Hugh Kearney, Yvonne M. Purcell, Christopher McGuigan, more

Irish Journal of Medical Science ( 01971 -) > 2018 > 187 > 3 > 781-787

Magnetic resonance imaging (MRI) plays an integral role in the management of multiple sclerosis (MS), from both diagnostic and therapeutic perspectives. This 2-part review aims to detail the evolving and expanding role of MRI for both radiologists and neurologists. In this article, we discuss the diagnostic criteria for MS relevant to radiologists, as well as its varying imaging manifestations. The...

article

Neuromyelitis optica presenting as intractable vomiting and hyperCKaemia

Tarig Mohammed Abkur, Eílis Foran, Hugh Kearney, Grace Harkin, more

Journal of Neurology > 2016 > 263 > 1 > 171-173

article

Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis

Marios C. Yiannakas, Ahmed M. Mustafa, Benjamin De Leener, Hugh Kearney, more

NeuroImage: Clinical > 2016 > 10 > C > 71-77

Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI). However, segmentation methods have been limited by factors relating to reproducibility or sensitivity to change. The purpose of this study was to evaluate a fully automated SC segmentation method (PropSeg), and compare this...

article

Improved MRI quantification of spinal cord atrophy in multiple sclerosis

Hugh Kearney, Marios C. Yiannakas, Khaled Abdel‐Aziz, Claudia A.M. Wheeler‐Kingshott, more

Journal of Magnetic Resonance Imaging > 39 > 3 > 617 - 623

PurposeTo identify an improved method for measuring spinal cord cross‐sectional area (CSA) using magnetic resonance imaging (MRI) in multiple sclerosis (MS). Materials and MethodsMRI was performed on 15 controls and 15 MS patients and repeated in nine controls and nine patients after 6 months. At this timepoint, an additional scan was acquired to evaluate scan–rescan reproducibility. Two sequences...

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Search results for: Hugh Kearney

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