MicroRNAs (miRNAs) play crucial roles in head and neck squamous cell carcinoma (HNSCC). This study investigates whether miR‐31, miR‐96, and miR‐182 are involved in targeting Numb during HNSCC.
The expression of miR‐31/96/182 in tumor tissues was analyzed. Reporter assay, knockdown, expression, and oncogenic analysis were carried out in cell lines.
Upregulation of miR‐31/96/182...
Apurinic/apyrimidinic endonuclease 1/redox factor‐1 (APE1/Ref‐1) is a multifunctional protein involved in DNA repair and redox signaling. The purpose of this study was to investigate the relationship between APE1/Ref‐1 expression and clinicopathological features, survival, and treatment response in patients with oral squamous cell carcinoma (OSCC) and cell lines.
BackgroundSurgery followed by radiotherapy (RT) is indicated for patients with high‐risk oral cavity cancer (OCC). Based on multi‐institutional reports, we developed a guideline for postoperative RT for patients with OCC.
MethodsA multidisciplinary OCC team was recruited to develop a questionnaire concerning details of risk‐factor categorization, target delineation, and dose specification. Thirty‐one...
BackgroundOral carcinoma is an important malignancy throughout the world. MicroRNAs (miRNAs) are endogenously expressed, non‐coding RNAs that regulate post‐transcriptional levels of targeted mRNAs. MiRNA‐31(miR‐31) is significantly upregulated in oral carcinoma tissues and plays oncogenic roles in oral carcinogenesis.
MethodsWe analyzed the levels of miR‐31 in saliva of patients with oral carcinoma...
BackgroundAreca nut chewing is a common oral habit of Asians that is closely associated with the high incidence of head and neck carcinoma. The purpose of this study was to investigate the impacts of areca nut chewing on neoplastic process of head and neck carcinoma.
MethodsHead and neck carcinoma cells were treated with areca nut extract to perceive the phenotypic impacts. Tumor tissues were analyzed...
Background.Validating markers for prediction of nodal metastasis could be beneficial in treatment of oral cavity cancer. Decoy receptor 3 (DcR3), locus on 20q13, functions as a death decoy inhibiting apoptosis mediated by the tumor necrosis factor receptor (TNFR) family.
Methods.This study analyzed the serum level of DcR3 in relationship to the clinical parameters of oral cavity cancer patients together...
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SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.