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Background:Transfusion of D+ red blood cells (RBCs) to D− recipients can be accidental or necessary due to D− RBC shortage. Alloimmunization can complicate future transfusions; implications for women of childbearing age are compounded by possible hemolytic disease of the fetus and newborn. Rh immunoprophylaxis is effective, and indicated, for preventing alloimmunization. Reports of massive D+ mismatch...