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We previously reported that concurrent ketoconazole, an oral anti‐fungal agent and P450 enzyme inhibitor, increased plasma levels of the cytotoxic retinoid, fenretinide (4‐HPR) in mice. We have now determined the effects of concurrent ketoconazole on 4‐HPR cytotoxic dose‐response in four neuroblastoma (NB) cell lines in vitro and on 4‐HPR activity against two cell line‐derived, subcutaneous NB xenografts...