Search results for: Mirjana Gavella

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article

Ganglioside GT1b protects human spermatozoa from hydrogen peroxide‐induced DNA and membrane damage

Mirjana Gavella, Verica Garaj‐Vrhovac, Vaskresenija Lipovac, Mariastefania Antica, more

International Journal of Andrology > 33 > 3 > 536 - 544

We have reported previously that various gangliosides, the sialic acid containing glycosphingolipids, provide protection against sperm injury caused by reactive oxygen species (ROS). In this study, we investigated the effect of treatment of human spermatozoa with ganglioside GT1b on hydrogen peroxide (H₂O₂)‐induced DNA fragmentation and plasma membrane damage. Single‐cell gel electrophoresis (Comet...

article

Effect of gangliosides on the copper-induced oxidation of human low-density lipoproteins

Marina Kveder, Greta Pifat, Mirjana Gavella, Vaskresenija Lipovac

Biophysical Chemistry > 2003 > 104 > 1 > 45-54

The role of gangliosides in the copper-induced oxidative modification of human low-density lipoprotein (LDL) was studied focusing on the early stage of LDL oxidation in which the concentration of conjugated dienes increases only weakly. The changes in the protein and lipid component were followed using fluorescence spectroscopy. The results indicate that binding of gangliosides to LDL causes slower...

article

Age-associated alteration of lipid peroxidation and superoxide dismutase activity in CBA and AKR mice

Višnja Šverko, Tihomir Balog, Sandra Sobočanec, Mirjana Gavella, more

Experimental Gerontology > 2002 > 37 > 8-9 > 1031-1039

Oxidative modification of lipids, proteins and DNA by reactive oxygen species in the organism and imbalance between the concentrations of free radicals and the antioxidant defenses may be related to processes such as aging and diseases (cardiovascular, neurodegenerative, cancer, etc.). Although the relationship between oxidant status and antioxidant defence in aging of different species, organs or...

article

Effect of cisplatin and 6-bromo-6-deoxy-l-ascorbic acid on some biochemical and functional parameters in mice

Višnja Šverko, Marko Radačić, Mirjana Gavella, Vaskrsenija Lipovac, more

Toxicology > 1999 > 137 > 1 > 23 - 34

The results of the present study demonstrate that 6-bromo-6-deoxy-l-ascorbic acid (6-BrAA), an antioxidative derivative of ascorbic acid, is capable of lowering the toxicity of cisplatin, cis-diaminedichloroplatinum (cis-DDP), an anticancerogenic drug. The biological aspects and pharmacological significance of a combined treatment of these two substances were investigated in a mouse model. The results...

article

Paraoxonase and arylesterase activities in the serum of two hyperlipoproteinaemic patients after repeated extracorporal lipid precipitation

Elsa Reiner, Draženka Svedružić, Vera Simeon-Rudolf, Vaskresenija Lipovac, more

Chemico-Biological Interactions > 1999 > 119-120 > Complete > 405-411

The effect of heparin-induced extracorporal lipid precipitation (HELP) on the activities of paraoxonase (EC 3.1.8.1) and arylesterase (EC 3.1.1.2) was studied in serum of a patient with hyperlipoproteinaemia (A) and of a patient with non-insulin dependent diabetes mellitus and hyperlipoproteinaemia (B). The enzyme activities were measured spectrophotometrically (Tris–HCl buffer, pH 7.4, 37°C) with...

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Keywords

LIPID PEROXIDATION (2)
SIALIC ACID (2)
6-BROMO-6-DEOXY-L-ASCORBIC ACID (1)
AGING (1)
AKR MICE (1)
CBA MICE (1)
CIS-DICHLORODIAMINEPLATINUM (1)
DNA DAMAGE (1)
FLUORESCENCE (1)
GANGLIOSIDE (1)
GANGLIOSIDES (1)
HEPARIN-INDUCED EXTRACORPORAL LIPID PRECIPITATION (HELP) (1)
HUMAN SERUM ARYLESTERASE (1)
HUMAN SERUM PARAOXONASE (1)
HYDROGEN PEROXIDE (1)
HYPERLIPOPROTEINAEMIA (1)
LDL (1)
LYSOSOMES (1)
OXIDATION (1)
SPERMATOZOA (1)
SUPEROXIDE DISMUTASE (1)
THYMOMA (1)
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Elsevier (4)
Wiley (1)

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Search results for: Mirjana Gavella

Ganglioside GT1b protects human spermatozoa from hydrogen peroxide‐induced DNA and membrane damage

Effect of gangliosides on the copper-induced oxidation of human low-density lipoproteins

Age-associated alteration of lipid peroxidation and superoxide dismutase activity in CBA and AKR mice

Effect of cisplatin and 6-bromo-6-deoxy-l-ascorbic acid on some biochemical and functional parameters in mice

Paraoxonase and arylesterase activities in the serum of two hyperlipoproteinaemic patients after repeated extracorporal lipid precipitation

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