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Aims: Peptide YY (PYY) is an endogenous anorectic gut‐secreted peptide that has been shown to suppress appetite in animals and humans, when given by injection. This study tested if needle‐free pulmonary delivery of PYY enables food intake suppression and reduced body weight gain in rats. The PYY pharmacokinetics and effects on brain neuropeptide levels were also examined.
Methods: Rats received single...