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BACKGROUNDAdrenal/intratumoral androgen biosynthesis contributes to ligand‐dependent androgen receptor activation in metastatic castration‐resistant prostate cancer (mCRCP). Compounds targeting CYP‐17 hydroxylase and lyase, as ketoconazole and abiraterone, block adrenal/intratumoral androgen biosynthesis, and are used as sequential endocrine approaches in mCRCP. We aimed to describe contemporary experience...
BACKGROUNDWe sought to determine the change of PSA doubling time (PSADT) and its association with disease progression during intermittent androgen deprivation (IAD) therapy for prostate cancer.
METHODSData were retrospectively analyzed in 96 patients with biochemically relapsed prostate cancer (BRPC) treated with IAD since 1995. IAD consisted of LHRH‐agonists ± antiandrogen given usually at PSA threshold...
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