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A novel amplifier system was designed and prepared for low-noise recording of pico-ampere current in nanopore experiment (< 100 pA). As an example, the amplifier system was applied in α-hemolysin based nanopore detection of DNA-PEG-DNA conjugate to record the signals of translocation and bumping events in buffer solution (1 M KCl, 10 mM Tris-HCl, 1 mM EDTA, pH 8.0). The amplified current signal...
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