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The interactions between human serum albumin (HSA) and fluphenazine (FPZ) in the presence or absence of rutin or quercetin were studied by fluorescence, absorption and circular dichroism (CD) spectroscopy and molecular modeling. The results showed that the fluorescence quenching mechanism was static quenching by the formation of an HSA–FPZ complex. Entropy change (ΔS0) and enthalpy change (ΔH0) values...
Nifedipine (NDP) is used extensively for the clinical treatment of a number of cardiovascular diseases. Herein, the interaction between human serum albumin (HSA) and NDP and the influence of flavonoids, rutin and baicalin, on their binding properties were investigated in vitro by means of fluorescence and absorption spectroscopy. The fluorescence of HSA was quenched remarkably by NDP and the quenching...
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