Search results for: Joana Reis

Items from 1 to 19 out of 19 results

article

Association of amygdala size with stress perception: Findings of a transversal study across the lifespan

Inês Caetano, Liliana Amorim, Teresa Costa Castanho, Ana Coelho, more

European Journal of Neuroscience > 56 > 8 > 5287 - 5298

Daily routines are getting increasingly stressful. Interestingly, associations between stress perception and amygdala volume, a brain region implicated in emotional behaviour, have been observed in both younger and older adults. Life stress, on the other hand, has become pervasive and is no longer restricted to a specific age group or life stage. As a result, it is vital to consider stress as a continuum...

article

Implications of a defined daily dose fixed database for drug utilization research studies: The case of statins in Portugal

Catarina Abrantes, Fernanda S. Tonin, Joana Reis‐Pardal, Margarida Castel‐Branco, more

British Journal of Clinical Pharmacology > 87 > 9 > 3542 - 3549

Aims Given the discrepancies between PDDs (prescribed daily doses) and DDDs (defined daily doses), we aimed to assess the extent of error in the results of an 18‐year population‐level study on statin utilization in Portugal. Methods The Portuguese regulatory agency provided data for the period 2000–2018 on statin dispensing (C10AA). The DDDs were gathered from the ATC/DDD database. DDDs were calculated...

article

Breast sarcoidosis: Clinical features, imaging, and histological findings

Joana Reis, Joao Boavida, Nazli Bahrami, Marianne Lyngra, more

The Breast Journal > 27 > 1 > 44 - 47

Breast sarcoidosis is an extremely rare entity (about 1%). Conventional imaging significantly contributes to the detection of breast lesions, but it has been unable to establish a definite diagnosis. Histological examination should be mandatory, over imaging assessments, in order to confirm an early diagnosis and to avoid unjustified treatments. Malignancy should be excluded as a primary differential...

article

Microtomographic characterization of calcifications in canine mammary tumours

Joana Reis, Teresa Oliveira, Alfredo Pereira, Paulo Infante, more

Veterinary and Comparative Oncology > 18 > 3 > 281 - 291

The present work describes the microtomographic characterization of macro‐ and microcalcifications present in excised canine mammary glands. In human breast cancer, microcalcifications are highly relevant for diagnosis and prognosis, often being the sole element determining biopsy. Canine mammary tumours are considered a model for human breast cancer, but the morphological features of calcifications...

article

Local identity as an amplifier: Procedural justice, local identity and attitudes towards new dam projects

Sibila Marques, Maria Luísa Lima, Sérgio Moreira, Joana Reis

Journal of Environmental Psychology > 2015 > 44 > C > 63-73

Local environmental changes are complex processes that are not always easily accepted by the communities. Research has shown that perceived procedural justice is a key variable in understanding these debates. From a perspective based on Social Identity Theory, we hypothesize in this paper that this effect will be particularly stronger for those that have a high degree of place identity, at least in...

chapter

Epileptic event detection algorithm for ambulatory monitoring platforms

F. Pinho, Joao Ferreira, Joana Reis, N. J. Sousa, more

2014 IEEE International Symposium on Medical Measurements and Applications (MeMeA) > 1 - 6

2014 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

Detecting epileptic electroencephalography (EEG) signals, both automatically and accurately, is significant in ambulatory long-term monitoring patients with epilepsy. In this study, it is presented a novel epileptic-like event detection algorithm based on a mixture of amplitude, frequency and spatial analysis with rule-based decision. In this work, EEG signals from 6 different subjects were searched...

article

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Tiago Silva, Joana Reis, José Teixeira, Fernanda Borges

Ageing Research Reviews > 2014 > 15 > Complete > 116-145

Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly destroys brain cells. This disease progressively compromises both memory and cognition, culminating in a state of full dependence and dementia. Currently, AD is the main cause of dementia in the elderly and its prevalence in the developed world is increasing rapidly. Classic drugs, such as acetylcholinesterase inhibitors...

article

Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides

Joana Reis, Alexandra Gaspar, Fernanda Borges, Ligia Rebelo Gomes, more

Journal of Molecular Structure > 2014 > 1056-1057 > Complete > 31-37

The chromone scaffold has been found to be an important tool in the drug discovery process through its relevant pharmacological activities. Chromone carboxamide derivatives synthesized within our group have shown noteworthy results as inhibitors of monoamino oxidase-B and as ligands for adesonine receptors. Specifically, chromone-2-carboxamide has been shown to be a privileged structure for the development...

article

4‐Oxo‐N‐phenyl‐4H‐chromene‐2‐carboxamide and of a new polymorph of 7‐methoxy‐4‐oxo‐N‐p‐tolyl‐4H‐chromene‐2‐carboxamide and its hemihydrate

Joana Reis, Alexandra Gaspar, Fernanda Borges, Ligia R. Gomes, more

Acta Crystallographica Section C > 69 > 12 > 1527 - 1533

4‐Oxo‐N‐phenyl‐4H‐chromene‐2‐carboxamide, C₁₆H₁₁NO₃, crystallizes in the space group P2₁/n and its derivative 7‐methoxy‐4‐oxo‐N‐p‐tolyl‐4H‐chromene‐2‐carboxamide, C₁₈H₁₅NO₄, forms two polymorphs which crystallize in the space groups P2₁/c and P. The structures have an anti‐rotamer conformation about the C—N bond; however, the amide O atom can be either trans‐ or cis‐related to the O atom of the pyran...

article

A process-dissociation analysis of semantic illusions

André Mata, Mário Boto Ferreira, Joana Reis

Acta Psychologica > 2013 > 144 > 2 > 433-443

We examine semantic illusions from a dual-process perspective according to which the processes that go into failing or succeeding to detect such illusions can be decomposed into controlled processes (checking the facts in the sentence against the information in memory) and automatic processes (the impression of truth that comes from the semantic associations between the elements in the sentence)....

article

Synthesis and NMR studies of novel chromone‐2‐carboxamide derivatives

Alexandra Gaspar, Fernando Cagide, Elias Quezada, Joana Reis, more

Magnetic Resonance in Chemistry > 51 > 4 > 251 - 254

Chromones are heterocyclic compounds of natural or synthetic origin that possess relevant pharmacological activities. Versatile functionalization of the chromone nucleus allows attaining of a chemical diversity suitable to perform structure–activity relationships in drug discovery and development programs. Accordingly, the synthesis and identification of novel chromone carboxamide derivatives with...

article

Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors

Aliuska Morales Helguera, Alfonso Pérez-Garrido, Alexandra Gaspar, Joana Reis, more

European Journal of Medicinal Chemistry > 2013 > 59 > Complete > 75-90

Due to their role in the metabolism of monoamine neurotransmitters, MAO-A and MAO-B present a significant pharmacological interest. For instance the inhibitors of human MAO-B are considered useful tools for the treatment of Parkinson Disease. Therefore, the rational design and synthesis of new MAOs inhibitors is considered of great importance for the development of new and more effective treatments...

article

In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton

Alexandra Gaspar, Joana Reis, Maria João Matos, Eugenio Uriarte, more

European Journal of Medicinal Chemistry > 2012 > 54 > Complete > 914-918

A selected series of chromone carboxamides synthesized in our laboratory were evaluated by radioligand binding studies towards adenosine receptors. All the chromone-3-carboxamides (compounds 8–12) exhibit A _2B receptor displacement percentage superior to 50%. The best results were obtained with phenolic substituents (compounds 9 and 12) in the position 3 of pyrone ring with a K _i value...

article

PIEZOELECTRIC ACTUATORS FOR BONE MECHANICAL STIMULATION: EXPLORING THE CONCEPT

Joana Reis, Clara Frias, Fernando Capela-Silva, José Potes, more

Journal of Biomechanics > 2012 > 45 > Supplement 1 > S344

article

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

Alexandra Gaspar, Joana Reis, Sonja Kachler, Silvia Paoletta, more

Biochemical Pharmacology > 2012 > 84 > 1 > 21-29

A project focused on the discovery of new chemical entities (NCEs) as AR ligands that incorporate a benzo-γ-pyrone [(4H)-1-benzopyran-4-one] substructure has been developed. Accordingly, two series of novel chromone carboxamides placed at positions C2 (compounds 2–13) and C3 (compounds 15–26) of the γ-pyrone ring were synthesized using chromone carboxylic acids (compounds 1 or 14) as starting materials...

article

Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis

Fernando Cagide, Joana Reis, Alexandra Gaspar, Fernanda Borges

Tetrahedron Letters > 2011 > 52 > 48 > 6446-6449

Microwave irradiation offers a considerable advantage over conventional synthesis with rate enhancements and cleaner reactions. Accordingly, a new microwave-assisted method for the synthesis of functionalized chromones was developed allowing the obtention of a library of chromone carboxamides. The method has been shown to present several advantages including operational simplicity, good performance,...

article

Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors

Alexandra Gaspar, Joana Reis, André Fonseca, Nuno Milhazes, more

Bioorganic & Medicinal Chemistry Letters > 2011 > 21 > 2 > 707-709

Monoamine oxidase (MAO) is an enzyme, present in mammals in two isoforms MAO-A and MAO-B. These isoforms have a crucial role in neurotransmitters metabolism, representing an attractive drug target in the therapy of neurodegenerative diseases (MAO-B) and depression (MAO-A). In this context, our work has been focused on the discovery of new chemical entities (NCEs) for MAO inhibition, based on the development...

article

Antixenosis resistance to leaf miner Leucoptera coffeella in Coffea species

José Wilacildo Matos, Oliveiro Guerreiro-Filho, Wallace Gonçalves, Daniel Alves Ramiro, more

Euphytica > 2011 > 181 > 2 > 253-260

The coffee leaf miner, Leucoptera coffeella, is the most important pest of Coffea arabica plantations in Brazil, and all cultivars are susceptible to the insect. However, distinct reactions have been observed in other species, such as C. congensis and C. canephora. In this work, the occurrence of antixenotic response was surveyed in individuals of Coffea species, selected for resistance to the leaf...

article

RAPID MANUFACTURING SYSTEM OF ORTHOPEDIC IMPLANTS

Carlos Relvas, Joana Reis, José Alberto Caeiro Potes, Fernando Manuel Ferreira Fonseca, more

Revista Brasileira de Ortopedia (English Edition) > 2009 > 44 > 3 > 260-265

This study, aimed the development of a methodology for rapid manufacture of orthopedic implants simultaneously with the surgical intervention, considering two potential applications in the fields of orthopedics: the manufacture of anatomically adapted implants and implants for bone loss replacement. This work innovation consists on the capitation of the in situ geometry of the implant by direct capture...

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