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Background
Parkinson's disease (PD) disrupts motor performance by affecting the basal ganglia system. Yet, despite the critical position of the primary motor cortex in linking basal ganglia computations with motor performance, its contribution to motor disability in PD is largely unknown. The objective of this study was to characterize the role of the primary motor cortex in PD‐related motor disability...
Objective
To investigate the network dynamics mechanisms underlying differential initiation of epileptic interictal spikes and seizures.
Methods
We performed combined in vivo 2‐photon calcium imaging from different targeted neuronal subpopulations and extracellular electrophysiological recordings during 4‐aminopyridine–induced neocortical spikes and seizures.
Results
Both spikes and seizures...
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