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Single‐cell mass spectrometry (MS) is significant in biochemical analysis and holds great potential in biomedical applications. Efficient sample preparation like sorting (i.e., separating target cells from the mixed population) and desalting (i.e., moving the cells off non‐volatile salt solution) is urgently required in single‐cell MS. However, traditional sample preparation methods suffer from complicated...
Single‐Cell Mass Spectrometry
In article number 2310700, Wenhui Wang and co‐workers proposed a one‐step sample preparation strategy by leveraging label‐free microfluidic impedance flow cytometry to solve the problem of simultaneous sorting and desalting of single cells. This strategy enables to flow mixed cell samples into the microfluidic chip, and then collect the target cell samples with desired...
Dielectrophoresis (DEP) particle separation has label‐free, well‐controllable, and low‐damage merits. Sidewall microelectrodes made of liquid metal alloy (LMA) inherits the additional advantage of thick electrodes to generate impactful DEP force. However, existing LMA electrode‐based devices lack the ability to integrate large‐array electrodes in a compact footprint, severely limiting flow rate and...
Liquid Metal Alloy Electrodes
A facile and versatile method is proposed to fabricate unlimited array of thick liquid metal alloy (LMA) electrodes, suitable for flexible electronics and functional materials etc. In article number 2310212, Liang Huang, Wenhui Wang, and co‐workers demonstrate LMA electrodes in microfluidics to bring the accumulative dielectrophoretic (DEP) deflection effect. 5000‐LMA‐electrode...
Reflecting various physiological states and phenotypes of single cells, intrinsic biophysical characteristics (e.g., mechanical and electrical properties) are reliable and important, label‐free biomarkers for characterizing single cells. However, single‐modal mechanical or electrical properties alone are not specific enough to characterize single cells accurately, and it has been long and challenging...
Intrinsic Bio‐Physical Properties
In article number 2303416, Wenhui Wang and co‐workers report an impedance‐based multimodal electrical‐mechanical flow cytometry framework working like an intelligent robot for 5D intrinsic characterization of single cells. Through specifically‐designed impedance‐property models and neural networks, the proposed multimodal framework removes the usual need of a camera...
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