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Background and Aims
Mothers against decapentaplegic homolog (SMAD) 7 is an antagonist of TGF‐β signaling. In the present investigation, we sought to determine the relevance of SMAD7 in liver carcinogenesis using in vitro and in vivo approaches.
Approach and Results
We found that SMAD7 is up‐regulated in a subset of human HCC samples with poor prognosis. Gene set enrichment analysis revealed that...
Background To help identify potential hepatocellular carcinoma (HCC) candidates for immunotherapies, we aimed to develop and validate a radiomics-based biomarker (Rad score) to predict the infiltration of tumor-infiltrating CD8+ T cells in HCC patients, and to evaluate the correlation of Rad score with tumor immune characteristics. Methods Overall, 142 HCC patients (n = 100 and n = 42 in the training...
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